Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex

Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in laye...

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Veröffentlicht in:	Nature neuroscience 2008-10, Vol.11 (10), p.1140-1142
Hauptverfasser:	Glazewski, Stanislaw, Fox, Kevin, Pervolaraki, Eleftheria, Hardingham, Neil, Phillips, Keith, Wright, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine brief-communication Cell receptors Cerebral cortex Long-Term Synaptic Depression - genetics Long-Term Synaptic Depression - physiology Mice Mice, Knockout Neural transmission Neurobiology Neurosciences Physiological aspects Receptors, AMPA - deficiency Receptors, AMPA - physiology Sensory Deprivation - physiology Somatosensory Cortex - anatomy & histology Somatosensory Cortex - physiology Synaptic Transmission - genetics Synaptic Transmission - physiology Vibrissae - innervation
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Zusammenfassung:	Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III-V, pathway.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn.2188