Bilateral Upper-Lobe Cavitary Pneumocystis carinii Pneumonia in a Patient on Dapsone Prophylaxis
Pneumocystis carinii pneumonia (PCP) presenting as bilateral upper-lobe cavitary disease is rare. Isolated upper-lobe involvement has traditionally been associated with aerosolized pentamidine prophylaxis. Dapsone is a cheap and effective prophylactic agent against P carinii in patients who cannot t...
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Veröffentlicht in: | The American journal of the medical sciences 1999-02, Vol.317 (2), p.137-139 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Pneumocystis carinii pneumonia (PCP) presenting as bilateral upper-lobe cavitary disease is rare. Isolated upper-lobe involvement has traditionally been associated with aerosolized pentamidine prophylaxis. Dapsone is a cheap and effective prophylactic agent against P carinii in patients who cannot tolerate trimethoprim-sulfamethoxazole. This is a case of a man who presented with bilateral upper-lobe cavitary P carinii pneumonia despite being on dapsone prophylaxis. Bronchoalveolar lavage was negative for P carinii. Transbronchial biopsy was positive for P carinii. The patient improved significantly with radiological resolution on specific treatment for P carinii. PCP should be included in the differential diagnosis of upper-lobe cavitary lung disease, and a transbronchial biopsy should be performed when the diagnosis is suspected. |
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ISSN: | 0002-9629 1538-2990 |
DOI: | 10.1016/S0002-9629(15)40488-4 |