Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys

Cobra venom factor (CVF)-induced consumption of complement proteins was used to investigate the role of complement in vivo in the immunopathogenesis of simian immunodeficiency virus of macaques (SIVmac) infection in rhesus monkeys. Repeated administration of CVF was shown to deplete complement to

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Veröffentlicht in:	AIDS research and human retroviruses 1999-01, Vol.15 (2), p.195-202
Hauptverfasser:	SCHMITZ, J. E, LIFTON, M. A, VOGEL, C.-W, LETVIN, N. L, REIMANN, K. A, MONTEFIORI, D. C, SHEN, L, RACZ, P, TENNER-RACZ, K, OLLERT, M. W, FORMAN, M. A, GELMAN, R. S
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Complement System Proteins - drug effects Elapid Venoms - administration & dosage Elapid Venoms - pharmacology Experimental viral diseases and models In Situ Hybridization Infectious diseases Lymph Nodes - virology Lymphocyte Count Macaca mulatta Macaca mulatta - virology Medical sciences Retroviridae Proteins - blood RNA, Viral - analysis Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - isolation & purification Simian Immunodeficiency Virus - pathogenicity Time Factors Viral diseases Viral Load Virus Replication
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Zusammenfassung:	Cobra venom factor (CVF)-induced consumption of complement proteins was used to investigate the role of complement in vivo in the immunopathogenesis of simian immunodeficiency virus of macaques (SIVmac) infection in rhesus monkeys. Repeated administration of CVF was shown to deplete complement to
ISSN:	0889-2229 1931-8405
DOI:	10.1089/088922299311619