Impact of early relapse after auto-SCT for multiple myeloma

Auto-SCT is an effective therapy for patients with multiple myeloma (MM), but nearly a fifth of these patients relapse within a year of auto-SCT. We studied 494 patients, undergoing auto-SCT within 12 months of diagnosis of MM. Patients were divided into two groups: early relapse (relapse ⩽12 months...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2008-09, Vol.42 (6), p.413-420
Hauptverfasser:	Kumar, S, Mahmood, S T, Lacy, M Q, Dispenzieri, A, Hayman, S R, Buadi, F K, Dingli, D, Rajkumar, S V, Litzow, M R, Gertz, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Cell Biology Clinical trials Development and progression Diagnosis Disease-Free Survival Female Hematology Hematopoietic stem cells Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - mortality Multiple Myeloma - therapy original-article Patients Prognosis Public Health Recurrence Retrospective Studies Stem Cell Transplantation Stem Cells Survival Rate Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Autologous
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Zusammenfassung:	Auto-SCT is an effective therapy for patients with multiple myeloma (MM), but nearly a fifth of these patients relapse within a year of auto-SCT. We studied 494 patients, undergoing auto-SCT within 12 months of diagnosis of MM. Patients were divided into two groups: early relapse (relapse ⩽12 months from auto-SCT) and late relapse (either relapsed >12 months after auto-SCT or disease free at the last follow up). One hundred twenty patients (24%) were in the early relapse and 374 (76%) were in the late-relapse groups. The early relapse group had a significantly shorter median overall survival (OS) from diagnosis (26.6 vs 90.7 months; P
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2008.180