Striatal uptake of a novel PET ligand, [18F]β-CFT, is reduced in early Parkinson's disease

[18F]β‐CFT is a novel PET ligand for dopamine reuptake sites. In this study, [18F]β‐CFT uptake was studied in nine patients with early Parkinson's disease (PD) without antiparkinsonian medication and in six age‐matched controls. The uptake of [18F]β‐CFT was calculated as a (region‐cerebellum)/c...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 1999-02, Vol.31 (2), p.119-124
Hauptverfasser:	Rinne, J.O., Bergman, J., Ruottinen, H., Haaparanta, M., Eronen, E., Oikonen, V., Sonninen, P., Solin, O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Caudate Nucleus - diagnostic imaging CFT Cocaine - analogs & derivatives Cocaine - pharmacokinetics dopamine dopamine reuptake Dopamine Uptake Inhibitors - pharmacokinetics Female Fluorine Radioisotopes - pharmacokinetics Humans Male Middle Aged Parkinson Disease - diagnostic imaging Parkinson Disease - metabolism Parkinson's disease PET positron emission tomography Putamen - diagnostic imaging Tomography, Emission-Computed
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Zusammenfassung:	[18F]β‐CFT is a novel PET ligand for dopamine reuptake sites. In this study, [18F]β‐CFT uptake was studied in nine patients with early Parkinson's disease (PD) without antiparkinsonian medication and in six age‐matched controls. The uptake of [18F]β‐CFT was calculated as a (region‐cerebellum)/cerebellum ratio at 150–210 min after injection. The mean uptake in the putamen contralateral to the predominant symptoms (1.04 ± 0.40, mean ± SD; P
ISSN:	0887-4476 1098-2396
DOI:	10.1002/(SICI)1098-2396(199902)31:2<119::AID-SYN4>3.0.CO;2-O