Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle

The present study was conducted to determine the effects of acute overload exercise on mitochondrial DNA and the structure of skeletal muscles. Rats were forced to run for 20 min until reaching complete exhaustion. We detected the large‐scale deletion (7052 bp) of mitochondrial DNA by the nested pol...

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Veröffentlicht in:	Muscle & nerve 1999-02, Vol.22 (2), p.258-261
Hauptverfasser:	Sakai, Yasutomo, Iwamura, Yukio, Hayashi, Jun-Ichi, Yamamoto, Nao, Ohkoshi, Norio, Nagata, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	acute exercise Animals Biological and medical sciences blood lactate DNA Damage DNA, Mitochondrial - genetics Fundamental and applied biological sciences. Psychology Male Microscopy, Electron Mitochondria - ultrastructure mitochondrial DNA deletion mitochondrial swelling Muscle Fatigue - physiology Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscle, Skeletal - ultrastructure Physical Exertion - physiology Polymerase Chain Reaction rat soleus Rats Rats, Wistar Space life sciences Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Zusammenfassung:	The present study was conducted to determine the effects of acute overload exercise on mitochondrial DNA and the structure of skeletal muscles. Rats were forced to run for 20 min until reaching complete exhaustion. We detected the large‐scale deletion (7052 bp) of mitochondrial DNA by the nested polymerase chain reaction, and also observed mitochondrial ultrastructural changes in the soleus muscle. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 258–261, 1999
ISSN:	0148-639X 1097-4598
DOI:	10.1002/(SICI)1097-4598(199902)22:2<258::AID-MUS15>3.0.CO;2-1