Calcium channels, neuromuscular synaptic transmission and neurological diseases
Abstract Voltage-dependent calcium channels are essential in neuronal signaling and synaptic transmission, and their functional alterations underlie numerous human disorders whether monogenic (e.g., ataxia, migraine, etc.) or autoimmune. We review recent work on CaV 2.1 or P/Q channelopathies, mostl...
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Veröffentlicht in: | Journal of neuroimmunology 2008-09, Vol.201, p.136-144 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Voltage-dependent calcium channels are essential in neuronal signaling and synaptic transmission, and their functional alterations underlie numerous human disorders whether monogenic (e.g., ataxia, migraine, etc.) or autoimmune. We review recent work on CaV 2.1 or P/Q channelopathies, mostly using neuromuscular junction preparations, and focus specially on the functional hierarchy among the calcium channels recruited to mediate neurotransmitter release when CaV 2.1 channels are mutated or depleted. In either case, synaptic transmission is greatly compromised; evidently, none of the reported functional replacements with other calcium channels compensates fully. |
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ISSN: | 0165-5728 1872-8421 |
DOI: | 10.1016/j.jneuroim.2008.06.031 |