Insulin-Mediated Vasodilation and Glucose Uptake Are Functionally Linked in Humans
Intra-arterial infusion of insulin in physiological doses causes forearm vasodilation which is augmented by co-infusion of D-glucose, leading us to speculate that local insulin-mediated vasodilation may depend on insulin-mediated glucose uptake. We have examined the relationship between whole-body i...
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Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-01, Vol.33 (1S Suppl), p.554-558 |
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Zusammenfassung: | Intra-arterial infusion of insulin in physiological doses causes forearm vasodilation which is augmented by co-infusion of D-glucose, leading us to speculate that local insulin-mediated vasodilation may depend on insulin-mediated glucose uptake. We have examined the relationship between whole-body insulin sensitivity and forearm vasodilation in response to local infusion of insulin/glucose, thus avoiding any confounding effects of sympathetic stimulation on peripheral blood flow. Eighteen healthy, normotensive male volunteers (age, 26 +/- 5.4 years) attended on two separate occasions for measurement of(1) whole-body insulin sensitivity with use of the hyperinsulinemic euglycemic clamp; (2) forearm vasodilation in response to an intra-arterial infusion of insulin/glucose with use of bilateral venous occlusion plethysmography. Insulin-mediated glucose uptake (M) for the group (mean +/- SD) was 10.0 +/- 2.2 mg [middle dot] kg [middle dot] min, and the percentage change in forearm blood flow ratio (%FBFR) for the group (median, interquartile range) was 28.2% (13.6, 48.6). In univariate analysis, M was significantly correlated with %FBFR (rs=0.60, P |
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ISSN: | 0194-911X 1524-4563 |
DOI: | 10.1161/01.hyp.33.1.554 |