Plasma exchange versus intravenous immunoglobulin treatment in myasthenic crisis

We performed a retrospective multicenter chart review to compare the efficacy and tolerance of plasma exchange (PE) and intravenous immunoglobulin (i.v.Ig) in treatment of 54 episodes of myasthenic crisis. After adjustment for other variables, PE (compared with i.v.Ig) was associated with a superior...

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Veröffentlicht in:	Neurology 1999-02, Vol.52 (3), p.629-632
Hauptverfasser:	QURESHI, A. I, CHOUDHRY, M. A, AKBAR, M. S, MOHAMMAD, Y, CHUA, H. C, YAHIA, A. M, ULATOWSKI, J. A, KRENDEL, D. A, LESHNER, R. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Diseases of striated muscles. Neuromuscular diseases Female Humans Immunoglobulins, Intravenous - therapeutic use Male Medical sciences Middle Aged Myasthenia Gravis - physiopathology Myasthenia Gravis - therapy Neurology Plasma Exchange Prognosis Retrospective Studies
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Zusammenfassung:	We performed a retrospective multicenter chart review to compare the efficacy and tolerance of plasma exchange (PE) and intravenous immunoglobulin (i.v.Ig) in treatment of 54 episodes of myasthenic crisis. After adjustment for other variables, PE (compared with i.v.Ig) was associated with a superior ventilatory status at 2 weeks (partial F = 6.2, p = 0.02) and 1 month functional outcome (partial F = 4.5, p = 0.04). However, the complication rate was higher with PE compared with i.v.Ig (13 versus 5 episodes, p = 0.07).
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.52.3.629