Roles for adenosine A1- and A2-receptors in the control of thyrotrophin and prolactin release from the anterior pituitary gland
Adenosine has been implicated in various aspects of pituitary function but little is known of its role in the regulation of thyrotrophin (TSH) release. This study examined the effects of adenosine deaminase (ADA, which provokes adenosine breakdown) and selective adenosine-receptor ligands on the sec...
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| Veröffentlicht in: | Regulatory peptides 1999, Vol.79 (1), p.41-46 |
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| creator | KUMARI, M BUCKINGHAM, J. C POYSER, R. H COVER, P. O |
| description | Adenosine has been implicated in various aspects of pituitary function but little is known of its role in the regulation of thyrotrophin (TSH) release. This study examined the effects of adenosine deaminase (ADA, which provokes adenosine breakdown) and selective adenosine-receptor ligands on the secretion of immunoreactive (ir-) TSH and prolactin (PRL) by rat anterior pituitary segments in vitro. ADA (5 U/ml) stimulated the release of both hormones (P |
| doi_str_mv | 10.1016/S0167-0115(98)00143-8 |
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However, the A2A-receptor selective agonist, CGS 21680 (1-100 nM) increased ir-TSH (P<0.05) and ir-PRL release (P<0.01); its effects on ir-TSH were blocked by concentrations of DPCPX (100 nM, P<0.01) sufficient to antagonize A2-receptors. These data suggest that adenosine acts via A1-receptors to tonically suppress ir-PRL and ir-TSH release but that A2A-receptor activation enhances the release of both hormones.]]></description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/S0167-0115(98)00143-8</identifier><identifier>PMID: 9930581</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. 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C</creatorcontrib><creatorcontrib>POYSER, R. H</creatorcontrib><creatorcontrib>COVER, P. O</creatorcontrib><title>Roles for adenosine A1- and A2-receptors in the control of thyrotrophin and prolactin release from the anterior pituitary gland</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description><![CDATA[Adenosine has been implicated in various aspects of pituitary function but little is known of its role in the regulation of thyrotrophin (TSH) release. This study examined the effects of adenosine deaminase (ADA, which provokes adenosine breakdown) and selective adenosine-receptor ligands on the secretion of immunoreactive (ir-) TSH and prolactin (PRL) by rat anterior pituitary segments in vitro. ADA (5 U/ml) stimulated the release of both hormones (P<0.01) as also did the selective adenosine A1-receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX, 0.1 & 1 nM, P<0.01); the responses to ADA were inhibited by an A1-receptor agonist, N6-cyclohexyladenosine (0.1-10 nM, P<0.01). A non-selective A1/A2-receptor agonist, N-cyclopropylcarboxamidoadenosine (1-100 nM) had mixed effects on ir-TSH release. However, the A2A-receptor selective agonist, CGS 21680 (1-100 nM) increased ir-TSH (P<0.05) and ir-PRL release (P<0.01); its effects on ir-TSH were blocked by concentrations of DPCPX (100 nM, P<0.01) sufficient to antagonize A2-receptors. These data suggest that adenosine acts via A1-receptors to tonically suppress ir-PRL and ir-TSH release but that A2A-receptor activation enhances the release of both hormones.]]></description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Prolactin - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Purinergic P1 - physiology</subject><subject>Thyrotropin - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUMtKxDAUDaKM4-MThCxEdFFNmqZJl8PgCwTBxzpk0lutdJqapItZ-eveeaAQbjicc-49HELOOLvmjJc3rzhUxjiXl5W-YowXItN7ZMq1EhkvdblPpn-SQ3IU4xeKpFJiQiZVJZjUfEp-XnwHkTY-UFtD72PbA53xjNq-prM8C-BgSD5E2vY0fQJ1vk_Bd9Q3CFfBIxg-kVvrBySsS4gCdGAj0Cb45cZm-wShxStDm8Y22bCiHx16TshBY7sIp7v_mLzf3b7NH7Kn5_vH-ewpc3mhU7ZwwJVQrC4qpqDQArgotK6hkLqwiPExLfO6AVcC5LJRWilrC57XsuQLcUwutnsx4_cIMZllGx10mAH8GE1ZSSVKIVAot0IXfIwBGjOEdol5DWdmXbzZFG_WrZpKm03xRqPvbHdgXCyh_nPtmkb-fMfb6GzXBNu7Nv4vLxWvmBS_M2SL2g</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>KUMARI, M</creator><creator>BUCKINGHAM, J. 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Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Prolactin - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Purinergic P1 - physiology</topic><topic>Thyrotropin - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUMARI, M</creatorcontrib><creatorcontrib>BUCKINGHAM, J. C</creatorcontrib><creatorcontrib>POYSER, R. H</creatorcontrib><creatorcontrib>COVER, P. 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O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles for adenosine A1- and A2-receptors in the control of thyrotrophin and prolactin release from the anterior pituitary gland</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1999</date><risdate>1999</risdate><volume>79</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract><![CDATA[Adenosine has been implicated in various aspects of pituitary function but little is known of its role in the regulation of thyrotrophin (TSH) release. This study examined the effects of adenosine deaminase (ADA, which provokes adenosine breakdown) and selective adenosine-receptor ligands on the secretion of immunoreactive (ir-) TSH and prolactin (PRL) by rat anterior pituitary segments in vitro. ADA (5 U/ml) stimulated the release of both hormones (P<0.01) as also did the selective adenosine A1-receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX, 0.1 & 1 nM, P<0.01); the responses to ADA were inhibited by an A1-receptor agonist, N6-cyclohexyladenosine (0.1-10 nM, P<0.01). A non-selective A1/A2-receptor agonist, N-cyclopropylcarboxamidoadenosine (1-100 nM) had mixed effects on ir-TSH release. However, the A2A-receptor selective agonist, CGS 21680 (1-100 nM) increased ir-TSH (P<0.05) and ir-PRL release (P<0.01); its effects on ir-TSH were blocked by concentrations of DPCPX (100 nM, P<0.01) sufficient to antagonize A2-receptors. These data suggest that adenosine acts via A1-receptors to tonically suppress ir-PRL and ir-TSH release but that A2A-receptor activation enhances the release of both hormones.]]></abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>9930581</pmid><doi>10.1016/S0167-0115(98)00143-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis In Vitro Techniques Male Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Prolactin - metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P1 - physiology Thyrotropin - metabolism Vertebrates: endocrinology |
| title | Roles for adenosine A1- and A2-receptors in the control of thyrotrophin and prolactin release from the anterior pituitary gland |
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