Roles for adenosine A1- and A2-receptors in the control of thyrotrophin and prolactin release from the anterior pituitary gland

Adenosine has been implicated in various aspects of pituitary function but little is known of its role in the regulation of thyrotrophin (TSH) release. This study examined the effects of adenosine deaminase (ADA, which provokes adenosine breakdown) and selective adenosine-receptor ligands on the sec...

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Veröffentlicht in:	Regulatory peptides 1999, Vol.79 (1), p.41-46
Hauptverfasser:	KUMARI, M, BUCKINGHAM, J. C, POYSER, R. H, COVER, P. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis In Vitro Techniques Male Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Prolactin - metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P1 - physiology Thyrotropin - metabolism Vertebrates: endocrinology
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Zusammenfassung:	Adenosine has been implicated in various aspects of pituitary function but little is known of its role in the regulation of thyrotrophin (TSH) release. This study examined the effects of adenosine deaminase (ADA, which provokes adenosine breakdown) and selective adenosine-receptor ligands on the secretion of immunoreactive (ir-) TSH and prolactin (PRL) by rat anterior pituitary segments in vitro. ADA (5 U/ml) stimulated the release of both hormones (P
ISSN:	0167-0115 1873-1686
DOI:	10.1016/S0167-0115(98)00143-8