Increased Karyotype Precision Using Fluorescence In Situ Hybridization and Spectral Karyotyping in Patients with Myeloid Malignancies

Increased Karyotype Precision Using Fluorescence In Situ Hybridization and Spectral Karyotyping in Patients with Myeloid Malignancies

We studied seven patients with various malignant hematologic disorders using fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were confirmed in two patients and the karyotypic precision was increased...

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Veröffentlicht in:Cancer genetics and cytogenetics 1999-01, Vol.108 (2), p.166-170
Hauptverfasser: Fleischman, Elena W., Reshmi, Shalini, Sokova, O.I., Kirichenko, O.P., Konstantinova, L.N., Kulagina, O.E., Frenkel, M.A., Rowley, Janet D.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Chromosome Banding
Female
Humans
In Situ Hybridization, Fluorescence - standards
Karyotyping - methods
Leukemia, Myeloid - genetics
Male
Middle Aged
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Zusammenfassung:We studied seven patients with various malignant hematologic disorders using fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were confirmed in two patients and the karyotypic precision was increased in five others using FISH and SKY. Two of three patients with 12p rearrangements had a deletion of one TEL allele. Thus, these newer techniques are an important adjunct to accurate chromosome analysis in malignancy.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(98)00137-X