Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women

Lipoproteins affect endothelium-dependent vasomotor responsiveness. Because lipoprotein effects of estrogen and cholesterol-lowering therapies differ, we studied the vascular responses to these therapies in hypercholesterolemic postmenopausal women. We randomly assigned 28 women to conjugated equine...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-01, Vol.99 (3), p.354-360
Hauptverfasser:	KWANG KON KOH, CARDILLO, C, BUI, M. N, HATHAWAY, L, CSAKO, G, WACLAWIW, M. A, PANZA, J. A, CANNON, R. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticholesteremic Agents - administration & dosage Biological and medical sciences Cholesterol, LDL - blood Drug Therapy, Combination E-Selectin - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Estrogens - administration & dosage Female Fibrinolysis - physiology General and cellular metabolism. Vitamins Hormone Replacement Therapy Humans Hypercholesterolemia - drug therapy Intercellular Adhesion Molecule-1 - metabolism Medical sciences Middle Aged Pharmacology. Drug treatments Plasminogen Activator Inhibitor 1 - blood Postmenopause Simvastatin - administration & dosage Vascular Cell Adhesion Molecule-1 - metabolism Vasculitis - drug therapy Vasodilation - drug effects Vasomotor System - drug effects
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Zusammenfassung:	Lipoproteins affect endothelium-dependent vasomotor responsiveness. Because lipoprotein effects of estrogen and cholesterol-lowering therapies differ, we studied the vascular responses to these therapies in hypercholesterolemic postmenopausal women. We randomly assigned 28 women to conjugated equine estrogen (CE) 0.625 mg, simvastatin 10 mg, and their combination daily for 6 weeks. Compared with respective baseline values, simvastatin alone and combined with CE reduced LDL cholesterol to a greater extent than CE alone (both P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.cir.99.3.354