New Acetylenic Enol Ethers of Glycerol from the Sponge Petrosia sp

Ten acetylenic enol ethers of glycerols, including six new compounds (1−6) and a linear acetylenic alcohol (7), have been isolated from a sponge of the genus Petrosia. The structures of the novel compounds were elucidated by spectroscopic methods. The absolute stereochemistry of 1−7 was determined by chemical transformations and the Mosher method. Some of these compounds exhibited weak cytotoxicity against a human leukemia cell-line (K-562).