Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndrome
Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in...
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| Veröffentlicht in: | Acta neurologica Scandinavica 1999-01, Vol.99 (1), p.26-35 |
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| container_title | Acta neurologica Scandinavica |
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| creator | Charlett, A. Dobbs, R. J. Dobbs, S. M. Weller, C. Brady, P. Peterson, D.W. |
| description | Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in their 39 siblings with double the number of controls, all obeying inclusion/exclusion criteria. Specific‐IgG antibody was assayed. Results ‐ Siblings, compared with controls, had brady/hypokinesia of gait (P > 0.002), bradykinesia of hands (P = 0.01), abnormal posture (P = 0.001), rigidity (P |
| doi_str_mv | 10.1111/j.1600-0404.1999.tb00654.x |
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J. ; Dobbs, S. M. ; Weller, C. ; Brady, P. ; Peterson, D.W.</creator><creatorcontrib>Charlett, A. ; Dobbs, R. J. ; Dobbs, S. M. ; Weller, C. ; Brady, P. ; Peterson, D.W.</creatorcontrib><description>Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in their 39 siblings with double the number of controls, all obeying inclusion/exclusion criteria. Specific‐IgG antibody was assayed. Results ‐ Siblings, compared with controls, had brady/hypokinesia of gait (P > 0.002), bradykinesia of hands (P = 0.01), abnormal posture (P = 0.001), rigidity (P <0.001) and seborrhoea/seborrhoeic dermatitis (P = 0.02). Both parkinsonians and siblings differed from controls in the odds of being H. pylori seropositive [odds ratios 3.04 (95% C.I.: 1.22, 7.63) and 2.94 (1.26, 6.86) respectively, P <0.02], seropositivity being found in 0.70 of sufferers. Conclusion ‐ Familial transmission of chronic infection plus part of syndrome links Helicobacter with causality. Seropositivity not being universal throughout parkinsonism, consequent on gastric atrophy sporadic antibiotic exposure, might explain less aggressive disease in older sufferers.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1111/j.1600-0404.1999.tb00654.x</identifier><identifier>PMID: 9925235</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; aetiology ; Age of Onset ; antibodies to Helicobacter pylori ; Antibodies, Bacterial - analysis ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; environmental insult ; Family Health ; Female ; Helicobacter Infections - immunology ; Helicobacter Infections - microbiology ; Helicobacter pylori - immunology ; Helicobacter pylori - pathogenicity ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parkinson Disease - genetics ; Parkinson Disease - microbiology ; Parkinson Disease, Secondary - genetics ; Parkinson Disease, Secondary - microbiology ; Pedigree ; quantification of facets of idiopathic parkinsonism ; seborrhoea/seborrhoeic dermatitis ; Serologic Tests ; siblings</subject><ispartof>Acta neurologica Scandinavica, 1999-01, Vol.99 (1), p.26-35</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4876-59f0ae831459f1c857de24a04d7e3e9298ff6ac4ce3cd3d88abf232a41681dae3</citedby><cites>FETCH-LOGICAL-c4876-59f0ae831459f1c857de24a04d7e3e9298ff6ac4ce3cd3d88abf232a41681dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0404.1999.tb00654.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0404.1999.tb00654.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1620171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9925235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Charlett, A.</creatorcontrib><creatorcontrib>Dobbs, R. J.</creatorcontrib><creatorcontrib>Dobbs, S. M.</creatorcontrib><creatorcontrib>Weller, C.</creatorcontrib><creatorcontrib>Brady, P.</creatorcontrib><creatorcontrib>Peterson, D.W.</creatorcontrib><title>Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndrome</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in their 39 siblings with double the number of controls, all obeying inclusion/exclusion criteria. Specific‐IgG antibody was assayed. Results ‐ Siblings, compared with controls, had brady/hypokinesia of gait (P > 0.002), bradykinesia of hands (P = 0.01), abnormal posture (P = 0.001), rigidity (P <0.001) and seborrhoea/seborrhoeic dermatitis (P = 0.02). Both parkinsonians and siblings differed from controls in the odds of being H. pylori seropositive [odds ratios 3.04 (95% C.I.: 1.22, 7.63) and 2.94 (1.26, 6.86) respectively, P <0.02], seropositivity being found in 0.70 of sufferers. Conclusion ‐ Familial transmission of chronic infection plus part of syndrome links Helicobacter with causality. Seropositivity not being universal throughout parkinsonism, consequent on gastric atrophy sporadic antibiotic exposure, might explain less aggressive disease in older sufferers.</description><subject>Adult</subject><subject>aetiology</subject><subject>Age of Onset</subject><subject>antibodies to Helicobacter pylori</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>environmental insult</subject><subject>Family Health</subject><subject>Female</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori - immunology</subject><subject>Helicobacter pylori - pathogenicity</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson Disease - microbiology</subject><subject>Parkinson Disease, Secondary - genetics</subject><subject>Parkinson Disease, Secondary - microbiology</subject><subject>Pedigree</subject><subject>quantification of facets of idiopathic parkinsonism</subject><subject>seborrhoea/seborrhoeic dermatitis</subject><subject>Serologic Tests</subject><subject>siblings</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv1DAQhS0EKtvCT0CKEOotqZ04TlyJQ1mVtlIpHBaQuFiOMwYvSbx4su3m3-PVRssZX-zRe29m9JmQt4xmLJ6LdcYEpSnllGdMSpmNDaWi5NnuGVkcpedkQSllqSgYf0lOEdexyivOT8iJlHmZF-WCfPuiw283oB8c9pcJuqZzw09M8JcOkNxC54xvtBkhJJup88ElCMFvPLrRPbpxSvTQJlYbGDHxNsFpaIPv4RV5YXWH8Hq-z8jXj9er5W16__nmbnl1nxpeVyItpaUa6rhgfDFTl1ULOdeUtxUUIHNZWyu04QYK0xZtXevG5kWuORM1azUUZ-T80HcT_J8t4Kh6hwa6Tg_gt6iELMtK0joaLw9GEzxiAKs2wfU6TIpRtYeq1mpPTu3JqT1UNUNVuxh-M0_ZNj20x-hMMervZl2j0Z0NejAO_00QOWUVi7b3B9uT62D6jwXU1cN1LmI-PeQdjrA75uMHKlEVVam-P9yoTx_Yj9WKrtSy-As9bKRj</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Charlett, A.</creator><creator>Dobbs, R. J.</creator><creator>Dobbs, S. M.</creator><creator>Weller, C.</creator><creator>Brady, P.</creator><creator>Peterson, D.W.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndrome</title><author>Charlett, A. ; Dobbs, R. J. ; Dobbs, S. M. ; Weller, C. ; Brady, P. ; Peterson, D.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4876-59f0ae831459f1c857de24a04d7e3e9298ff6ac4ce3cd3d88abf232a41681dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>aetiology</topic><topic>Age of Onset</topic><topic>antibodies to Helicobacter pylori</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>environmental insult</topic><topic>Family Health</topic><topic>Female</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori - immunology</topic><topic>Helicobacter pylori - pathogenicity</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson Disease - microbiology</topic><topic>Parkinson Disease, Secondary - genetics</topic><topic>Parkinson Disease, Secondary - microbiology</topic><topic>Pedigree</topic><topic>quantification of facets of idiopathic parkinsonism</topic><topic>seborrhoea/seborrhoeic dermatitis</topic><topic>Serologic Tests</topic><topic>siblings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Charlett, A.</creatorcontrib><creatorcontrib>Dobbs, R. J.</creatorcontrib><creatorcontrib>Dobbs, S. M.</creatorcontrib><creatorcontrib>Weller, C.</creatorcontrib><creatorcontrib>Brady, P.</creatorcontrib><creatorcontrib>Peterson, D.W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charlett, A.</au><au>Dobbs, R. J.</au><au>Dobbs, S. M.</au><au>Weller, C.</au><au>Brady, P.</au><au>Peterson, D.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndrome</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>1999-01</date><risdate>1999</risdate><volume>99</volume><issue>1</issue><spage>26</spage><epage>35</epage><pages>26-35</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in their 39 siblings with double the number of controls, all obeying inclusion/exclusion criteria. Specific‐IgG antibody was assayed. Results ‐ Siblings, compared with controls, had brady/hypokinesia of gait (P > 0.002), bradykinesia of hands (P = 0.01), abnormal posture (P = 0.001), rigidity (P <0.001) and seborrhoea/seborrhoeic dermatitis (P = 0.02). Both parkinsonians and siblings differed from controls in the odds of being H. pylori seropositive [odds ratios 3.04 (95% C.I.: 1.22, 7.63) and 2.94 (1.26, 6.86) respectively, P <0.02], seropositivity being found in 0.70 of sufferers. Conclusion ‐ Familial transmission of chronic infection plus part of syndrome links Helicobacter with causality. Seropositivity not being universal throughout parkinsonism, consequent on gastric atrophy sporadic antibiotic exposure, might explain less aggressive disease in older sufferers.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9925235</pmid><doi>10.1111/j.1600-0404.1999.tb00654.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult aetiology Age of Onset antibodies to Helicobacter pylori Antibodies, Bacterial - analysis Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases environmental insult Family Health Female Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter pylori - immunology Helicobacter pylori - pathogenicity Humans Male Medical sciences Middle Aged Neurology Parkinson Disease - genetics Parkinson Disease - microbiology Parkinson Disease, Secondary - genetics Parkinson Disease, Secondary - microbiology Pedigree quantification of facets of idiopathic parkinsonism seborrhoea/seborrhoeic dermatitis Serologic Tests siblings |
| title | Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndrome |
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