Parkinsonism: siblings share Helicobacter pylori seropositivity and facets of syndrome

Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in...

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Veröffentlicht in:Acta neurologica Scandinavica 1999-01, Vol.99 (1), p.26-35
Hauptverfasser: Charlett, A., Dobbs, R. J., Dobbs, S. M., Weller, C., Brady, P., Peterson, D.W.
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Sprache:eng
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Zusammenfassung:Objective ‐ Given a history of peptic ulcer is more frequent in parkinsonism, to investigate the role of Helicobacter pylori in its pathogenesis and of cross‐infection in familial aggregation. Methods ‐ Facets of parkinsonism were quantified in 33 elderly subjects with idiopathic parkinsonism and in their 39 siblings with double the number of controls, all obeying inclusion/exclusion criteria. Specific‐IgG antibody was assayed. Results ‐ Siblings, compared with controls, had brady/hypokinesia of gait (P > 0.002), bradykinesia of hands (P = 0.01), abnormal posture (P = 0.001), rigidity (P
ISSN:0001-6314
1600-0404
DOI:10.1111/j.1600-0404.1999.tb00654.x