Age-dependent impairment of angiogenesis

The effect of aging on angiogenesis in ischemic vascular disease has not been studied. Accordingly, we investigated the hypothesis that angiogenesis is impaired as a function of age. Forty days after the resection of 1 femoral artery, collateral vessel development was significantly impaired in old (...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-01, Vol.99 (1), p.111-120
Hauptverfasser:	RIVARD, A, FABRE, J.-E, SILVER, M, DONGFEN CHEN, MUROHARA, T, KEARNEY, M, MAGNER, M, ASAHARA, T, ISNER, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biological and medical sciences Cardiology. Vascular system Coronary heart disease Endothelial Growth Factors - genetics Endothelial Growth Factors - therapeutic use Follow-Up Studies Heart Hindlimb - blood supply Ischemia - drug therapy Ischemia - physiopathology Lymphocyte Count Lymphokines - genetics Lymphokines - therapeutic use Male Medical sciences Neovascularization, Physiologic - drug effects Nitric Oxide - biosynthesis Promoter Regions, Genetic Rabbits Recombinant Proteins - therapeutic use RNA, Messenger - biosynthesis T-Lymphocytes - pathology Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Vasomotor System - drug effects Vasomotor System - physiology
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Zusammenfassung:	The effect of aging on angiogenesis in ischemic vascular disease has not been studied. Accordingly, we investigated the hypothesis that angiogenesis is impaired as a function of age. Forty days after the resection of 1 femoral artery, collateral vessel development was significantly impaired in old (aged 4 to 5 years; n=7) versus young (aged 6 to 8 months; n=6) New Zealand White (NZW) rabbits on the basis of reduced hindlimb perfusion (ischemic: normal blood pressure ratio=0.58+/-0.05 versus 0.77+/-0.06; P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.cir.99.1.111