Hydroxylamine blocks adenosine A1 receptor-mediated inhibition of synaptic transmission in rat hippocampus

The nitric oxide donor hydroxylamine (NH2OH) induced a transient depression of the evoked synaptic potential recorded in the rat hippocampal CA1 region. This depression was abolished with an adenosine A1 antagonist, 8-cyclopentyltheophylline. In addition, hydroxylamine reversed adenosine A1 receptor...

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Veröffentlicht in:	Brain research 1999-01, Vol.815 (2), p.414-418
Hauptverfasser:	FOWLER, J. C, PARTRIDGE, L. D, GERVITZ, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Electrophysiology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - physiology Hydroxylamine - pharmacology In Vitro Techniques Male Neural Inhibition - drug effects Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Patch-Clamp Techniques Purinergic P1 Receptor Antagonists Rats Rats, Sprague-Dawley Receptors, Purinergic P1 - physiology Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs
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Zusammenfassung:	The nitric oxide donor hydroxylamine (NH2OH) induced a transient depression of the evoked synaptic potential recorded in the rat hippocampal CA1 region. This depression was abolished with an adenosine A1 antagonist, 8-cyclopentyltheophylline. In addition, hydroxylamine reversed adenosine A1 receptor-mediated inhibition of the evoked population spike, the fEPSP and the intracellularly recorded EPSP. The inhibitory modulation of adenosine A1 receptor activation by hydroxylamine suggests the presence of a potent endogenous regulatory site.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(98)01114-7