Zebrafish as a new animal model for movement disorders

The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic ne...

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Veröffentlicht in:	Journal of neurochemistry 2008-09, Vol.106 (5), p.1991-1997
Hauptverfasser:	Flinn, Laura, Bretaud, Sandrine, Lo, Christine, Ingham, Phillip W, Bandmann, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Antiparkinson Agents - pharmacology Biochemistry Biological and medical sciences Danio rerio Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal dopamine Drug Evaluation, Preclinical Fish Freshwater Genetic Predisposition to Disease - genetics Huntington Disease - drug therapy Huntington Disease - genetics Huntington Disease - physiopathology Huntington's disease Laboratory animals Medical sciences movement disorders Movement Disorders - drug therapy Movement Disorders - genetics Movement Disorders - physiopathology Mutation - genetics Neurology Neurotransmitters Organic mental disorders. Neuropsychology Parkinson disease Parkinson Disease - drug therapy Parkinson Disease - genetics Parkinson Disease - physiopathology Parkinson's disease Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry zebrafish Zebrafish - genetics Zebrafish - metabolism
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Beschreibung
Zusammenfassung:	The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high throughput in vivo drug screening.
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.2008.05463.x