Insulin-releasing activity of a series of phenylalanine derivatives

A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds ( S)- 3 and ( R)- 3 exhibited more potent insulin-releasing activity than that of nateglinide, compound ( S)- 3 also showed insulin-sensitizing activity in vitro. Both compounds were test...

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Veröffentlicht in:	European journal of medicinal chemistry 2008-09, Vol.43 (9), p.1997-2003
Hauptverfasser:	Tang, Lei, Yu, Juanhong, Wu, Haoshu, Fan, Houxing, Yang, Yushe, Ji, Ruyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cricetinae Drug Design General and cellular metabolism. Vitamins Hypoglycemia effect Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin-releasing activity Insulin-sensitizing activity Medical sciences Mice Pharmacology. Drug treatments Phenylalanine Phenylalanine - analogs & derivatives Phenylalanine - pharmacology
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Beschreibung
Zusammenfassung:	A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds ( S)- 3 and ( R)- 3 exhibited more potent insulin-releasing activity than that of nateglinide, compound ( S)- 3 also showed insulin-sensitizing activity in vitro. Both compounds were tested for hypoglycemia effect in vivo. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2007.11.018