Practical Heck−Mizoroki Coupling Protocol for Challenging Substrates Mediated by an N-Heterocyclic Carbene-Ligated Palladacycle

Practical Heck−Mizoroki Coupling Protocol for Challenging Substrates Mediated by an N-Heterocyclic Carbene-Ligated Palladacycle

A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck−Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide ra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2008-09, Vol.10 (18), p.3949-3952
Hauptverfasser: Kantchev, Eric Assen B, Peh, Guang-Rong, Zhang, Chi, Ying, Jackie Y
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Heterocyclic Compounds - chemistry
Methane - analogs & derivatives
Methane - chemistry
Organometallic Compounds - chemistry
Palladium - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck−Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol8012809