Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs
Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on...
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| Veröffentlicht in: | American journal of physiology: Gastrointestinal and liver physiology 2008-09, Vol.295 (3), p.G614-G620 |
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| container_title | American journal of physiology: Gastrointestinal and liver physiology |
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| creator | Chen, Jie Song, Geng-Qing Yin, Jieyun Koothan, Thillai Chen, J D Z |
| description | Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6+/-1.7 vs. 8.0+/-1.4, P |
| doi_str_mv | 10.1152/ajpgi.90322.2008 |
| format | Article |
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The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6+/-1.7 vs. 8.0+/-1.4, P<0.001). Naloxone partially blocked the effect of EA on antral contractions. 2) RD reduced the percentage of normal GSW from 98.8+/-0.8% at baseline to 76.1+/-8.6% (P<0.05) that was increased to 91.8+/-3.0% with EA. The effects of EA on the GSW were nullified by the presence of naloxone. 3) EA did not show any significant effect on rectal pressure, suggesting that the ameliorating effects of EA on RD-induced impaired gastric motility were not due to a decrease in rectal pressure. 4) EA increased the vagal activity suppressed by RD. In conclusion, RD inhibits postprandial gastric motility and impairs GSW in dogs, and the inhibitory effects are mediated via the adrenergic pathways. EA at ST36 is able to restore the RD-induced impaired GSW and motor activities, possibly by enhancing vagal activity, and is partially mediated via the opioid pathway. EA may have therapeutic potential for functional gastrointestinal disorders.</description><identifier>ISSN: 0193-1857</identifier><identifier>EISSN: 1522-1547</identifier><identifier>DOI: 10.1152/ajpgi.90322.2008</identifier><identifier>PMID: 18653722</identifier><identifier>CODEN: APGPDF</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adrenergic Agents - pharmacology ; Animals ; Catheterization ; Disease Models, Animal ; Dogs ; Electroacupuncture ; Excretory system ; Female ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - physiopathology ; Gastrointestinal Diseases - therapy ; Gastrointestinal Motility - drug effects ; Guanethidine - pharmacology ; Heart Rate ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Postprandial Period ; Pressure ; Rectum - drug effects ; Rectum - innervation ; Rectum - physiopathology ; Stomach - drug effects ; Stomach - innervation ; Stomach - physiopathology ; Studies ; Sympathetic Nervous System - physiopathology ; Vagus Nerve - physiopathology</subject><ispartof>American journal of physiology: Gastrointestinal and liver physiology, 2008-09, Vol.295 (3), p.G614-G620</ispartof><rights>Copyright American Physiological Society Sep 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-4035685b0588fed0359e1cb4cd82d57a8a26e20a1902c5b06c6899fa8bff1d153</citedby><cites>FETCH-LOGICAL-c324t-4035685b0588fed0359e1cb4cd82d57a8a26e20a1902c5b06c6899fa8bff1d153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3030,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18653722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Song, Geng-Qing</creatorcontrib><creatorcontrib>Yin, Jieyun</creatorcontrib><creatorcontrib>Koothan, Thillai</creatorcontrib><creatorcontrib>Chen, J D Z</creatorcontrib><title>Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs</title><title>American journal of physiology: Gastrointestinal and liver physiology</title><addtitle>Am J Physiol Gastrointest Liver Physiol</addtitle><description>Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6+/-1.7 vs. 8.0+/-1.4, P<0.001). Naloxone partially blocked the effect of EA on antral contractions. 2) RD reduced the percentage of normal GSW from 98.8+/-0.8% at baseline to 76.1+/-8.6% (P<0.05) that was increased to 91.8+/-3.0% with EA. The effects of EA on the GSW were nullified by the presence of naloxone. 3) EA did not show any significant effect on rectal pressure, suggesting that the ameliorating effects of EA on RD-induced impaired gastric motility were not due to a decrease in rectal pressure. 4) EA increased the vagal activity suppressed by RD. In conclusion, RD inhibits postprandial gastric motility and impairs GSW in dogs, and the inhibitory effects are mediated via the adrenergic pathways. EA at ST36 is able to restore the RD-induced impaired GSW and motor activities, possibly by enhancing vagal activity, and is partially mediated via the opioid pathway. EA may have therapeutic potential for functional gastrointestinal disorders.</description><subject>Adrenergic Agents - pharmacology</subject><subject>Animals</subject><subject>Catheterization</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Electroacupuncture</subject><subject>Excretory system</subject><subject>Female</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Gastrointestinal Diseases - therapy</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Guanethidine - pharmacology</subject><subject>Heart Rate</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Postprandial Period</subject><subject>Pressure</subject><subject>Rectum - drug effects</subject><subject>Rectum - innervation</subject><subject>Rectum - physiopathology</subject><subject>Stomach - drug effects</subject><subject>Stomach - innervation</subject><subject>Stomach - physiopathology</subject><subject>Studies</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Vagus Nerve - physiopathology</subject><issn>0193-1857</issn><issn>1522-1547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctLAzEQxoMotlbvniR48LY1j802e5RSH1DwoueQTbIlZXez5mHpf29aC4Knmcn85iMzHwC3GM0xZuRRbseNndeIEjInCPEzMM3PpMCsXJyDKcI1LTBniwm4CmGLEGIE40swwbxidEHIFNhVZ1T0Tqo0pkHF5A20_ejdtwmHRFpvNNzIEL1VsHfRdjbuoRw0DJ3bwZ08goNOKnPNHvosJzuobYhmCNYNuQm124RrcNHKLpibU5yBz-fVx_K1WL-_vC2f1oWipIxFiSirOGsQ47w1Ole1waopleZEs4XkklSGIIlrRFTGKlXxum4lb9oWa8zoDDz86uYlvpIJUfQ2KNN1cjAuBVHVjFKKSAbv_4Fbl_yQ_yYIJYxXmJcZQr-Q8i4Eb1oxettLvxcYiYMH4uiBOHogDh7kkbuTbmp6o_8GTkenP7VGhH8</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Chen, Jie</creator><creator>Song, Geng-Qing</creator><creator>Yin, Jieyun</creator><creator>Koothan, Thillai</creator><creator>Chen, J D Z</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs</title><author>Chen, Jie ; Song, Geng-Qing ; Yin, Jieyun ; Koothan, Thillai ; Chen, J D Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-4035685b0588fed0359e1cb4cd82d57a8a26e20a1902c5b06c6899fa8bff1d153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adrenergic Agents - pharmacology</topic><topic>Animals</topic><topic>Catheterization</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Electroacupuncture</topic><topic>Excretory system</topic><topic>Female</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - physiopathology</topic><topic>Gastrointestinal Diseases - therapy</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Guanethidine - pharmacology</topic><topic>Heart Rate</topic><topic>Naloxone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Postprandial Period</topic><topic>Pressure</topic><topic>Rectum - drug effects</topic><topic>Rectum - innervation</topic><topic>Rectum - physiopathology</topic><topic>Stomach - drug effects</topic><topic>Stomach - innervation</topic><topic>Stomach - physiopathology</topic><topic>Studies</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Vagus Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Song, Geng-Qing</creatorcontrib><creatorcontrib>Yin, Jieyun</creatorcontrib><creatorcontrib>Koothan, Thillai</creatorcontrib><creatorcontrib>Chen, J D Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: Gastrointestinal and liver physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jie</au><au>Song, Geng-Qing</au><au>Yin, Jieyun</au><au>Koothan, Thillai</au><au>Chen, J D Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs</atitle><jtitle>American journal of physiology: Gastrointestinal and liver physiology</jtitle><addtitle>Am J Physiol Gastrointest Liver Physiol</addtitle><date>2008-09</date><risdate>2008</risdate><volume>295</volume><issue>3</issue><spage>G614</spage><epage>G620</epage><pages>G614-G620</pages><issn>0193-1857</issn><eissn>1522-1547</eissn><coden>APGPDF</coden><abstract>Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6+/-1.7 vs. 8.0+/-1.4, P<0.001). Naloxone partially blocked the effect of EA on antral contractions. 2) RD reduced the percentage of normal GSW from 98.8+/-0.8% at baseline to 76.1+/-8.6% (P<0.05) that was increased to 91.8+/-3.0% with EA. The effects of EA on the GSW were nullified by the presence of naloxone. 3) EA did not show any significant effect on rectal pressure, suggesting that the ameliorating effects of EA on RD-induced impaired gastric motility were not due to a decrease in rectal pressure. 4) EA increased the vagal activity suppressed by RD. In conclusion, RD inhibits postprandial gastric motility and impairs GSW in dogs, and the inhibitory effects are mediated via the adrenergic pathways. EA at ST36 is able to restore the RD-induced impaired GSW and motor activities, possibly by enhancing vagal activity, and is partially mediated via the opioid pathway. EA may have therapeutic potential for functional gastrointestinal disorders.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>18653722</pmid><doi>10.1152/ajpgi.90322.2008</doi></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adrenergic Agents - pharmacology Animals Catheterization Disease Models, Animal Dogs Electroacupuncture Excretory system Female Gastrointestinal Diseases - etiology Gastrointestinal Diseases - physiopathology Gastrointestinal Diseases - therapy Gastrointestinal Motility - drug effects Guanethidine - pharmacology Heart Rate Naloxone - pharmacology Narcotic Antagonists - pharmacology Postprandial Period Pressure Rectum - drug effects Rectum - innervation Rectum - physiopathology Stomach - drug effects Stomach - innervation Stomach - physiopathology Studies Sympathetic Nervous System - physiopathology Vagus Nerve - physiopathology |
| title | Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs |
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