Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants

A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping s...

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Veröffentlicht in:	Biological psychology 2008-10, Vol.79 (2), p.239-242
Hauptverfasser:	Sigmund, Jessica C., Vogler, Christian, Huynh, Kim-Dung, de Quervain, Dominique J.-F., Papassotiropoulos, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Behavioral psychophysiology Biological and medical sciences Brain - anatomy & histology Brain - physiology Brain Mapping Case-Control Studies Female Fundamental and applied biological sciences. Psychology Genotype Hippocampus Histidine - genetics Humans Imputation Linkage Disequilibrium Male Memory - physiology Neuropsychological Tests Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide - genetics Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptor, Serotonin, 5-HT2A - genetics Serotonin Tyrosine - genetics Verbal Learning - physiology Young Adult
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Zusammenfassung:	A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.
ISSN:	0301-0511 1873-6246
DOI:	10.1016/j.biopsycho.2008.06.002