Total Synthesis of (+)-Cortistatin A

Total Synthesis of (+)-Cortistatin A

Marine engineering: A modular strategy featuring an intramolecular 1,4‐addition/aldol/dehydration cascade sequence (see scheme; TBS=tert‐butyldimethylsilyl) has enabled the total synthesis of cortistatin A, a potent anti‐angiogenic marine natural product. This flexible route offers access to other m...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-09, Vol.47 (38), p.7310-7313
Hauptverfasser: Nicolaou, K.C, Sun, Ya-Ping, Peng, Xiao-Shui, Polet, Damien, Chen, David Y.-K
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis Inhibitors - chemical synthesis
Angiogenesis Inhibitors - chemistry
antitumor agents
cascade reactions
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
natural products
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
total synthesis
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Zusammenfassung:Marine engineering: A modular strategy featuring an intramolecular 1,4‐addition/aldol/dehydration cascade sequence (see scheme; TBS=tert‐butyldimethylsilyl) has enabled the total synthesis of cortistatin A, a potent anti‐angiogenic marine natural product. This flexible route offers access to other members of the cortistatin family, both natural and designed.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200803550