Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus
Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is...
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| Veröffentlicht in: | The American journal of cardiology 2008-09, Vol.102 (6), p.700-703 |
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| creator | Jae, Sae Young, PhD Heffernan, Kevin S., MS Lee, Moon-Kyu, MD Fernhall, Bo, PhD Park, Won Hah, MD |
| description | Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p |
| doi_str_mv | 10.1016/j.amjcard.2008.05.012 |
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Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p <0.05), white blood cell count (r = −0.13, p <0.05), fibrinogen (r = −0.28, p <0.05), LP(a) (r = −0.53, p <0.05), tissue plasminogen activator (t-PA) antigen (r = −0.65, p <0.05), and plasminogen activator inhibitor-1 activity (r = −0.17, p <0.05). Men in the highest tertile of CRF had significantly lower CRP, white blood cell count, fibrinogen, LP(a), and t-PA than men in the lowest tertile of CRF (all p <0.05). In separate multivariable linear regression models that adjusted for age, body mass index, smoking, lipid profiles, glucose, and systolic blood pressure, CRP (β = −0.23, p <0.05), white blood cell count (β = −0.16, p <0.05), fibrinogen (β = −0.24, p <0.05), LP(a) (β = −0.28, p <0.05), and t-PA (β = −0.69, p <0.05) were each inversely associated with CRF. Each MET increment higher peak oxygen uptake was associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95% confidence interval 0.20 to 0.91) in a multivariate logistic regression model. In conclusion, CRF was inversely associated with inflammatory markers, fibrinolytic factors, and LP(a) in men with type 2 diabetes.]]></description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2008.05.012</identifier><identifier>PMID: 18773991</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Biological and medical sciences ; Biomarkers - blood ; Body Fat Distribution ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Physiological Phenomena ; Cholesterol - blood ; Correlation analysis ; Diabetes ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Exercise Test ; Fibrinogen - analysis ; Humans ; Leukocyte Count ; Leukocytes ; Lipoprotein(a) - blood ; Male ; Medical sciences ; Medical screening ; Middle Aged ; Mortality ; Oxygen Consumption - physiology ; Physical Fitness - physiology ; Plasminogen Activator Inhibitor 1 - blood ; Proteins ; Regression analysis ; Respiratory Physiological Phenomena ; Tissue Plasminogen Activator - blood</subject><ispartof>The American journal of cardiology, 2008-09, Vol.102 (6), p.700-703</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Sep 15, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-ebab5a6db18d56a4d89520fd60b8d351f9b4d1ab591ce4cf8fab1c2b738537873</citedby><cites>FETCH-LOGICAL-c475t-ebab5a6db18d56a4d89520fd60b8d351f9b4d1ab591ce4cf8fab1c2b738537873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914908008382$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20680606$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18773991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jae, Sae Young, PhD</creatorcontrib><creatorcontrib>Heffernan, Kevin S., MS</creatorcontrib><creatorcontrib>Lee, Moon-Kyu, MD</creatorcontrib><creatorcontrib>Fernhall, Bo, PhD</creatorcontrib><creatorcontrib>Park, Won Hah, MD</creatorcontrib><title>Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description><![CDATA[Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p <0.05), white blood cell count (r = −0.13, p <0.05), fibrinogen (r = −0.28, p <0.05), LP(a) (r = −0.53, p <0.05), tissue plasminogen activator (t-PA) antigen (r = −0.65, p <0.05), and plasminogen activator inhibitor-1 activity (r = −0.17, p <0.05). Men in the highest tertile of CRF had significantly lower CRP, white blood cell count, fibrinogen, LP(a), and t-PA than men in the lowest tertile of CRF (all p <0.05). In separate multivariable linear regression models that adjusted for age, body mass index, smoking, lipid profiles, glucose, and systolic blood pressure, CRP (β = −0.23, p <0.05), white blood cell count (β = −0.16, p <0.05), fibrinogen (β = −0.24, p <0.05), LP(a) (β = −0.28, p <0.05), and t-PA (β = −0.69, p <0.05) were each inversely associated with CRF. Each MET increment higher peak oxygen uptake was associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95% confidence interval 0.20 to 0.91) in a multivariate logistic regression model. In conclusion, CRF was inversely associated with inflammatory markers, fibrinolytic factors, and LP(a) in men with type 2 diabetes.]]></description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Body Fat Distribution</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cholesterol - blood</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Exercise Test</subject><subject>Fibrinogen - analysis</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Fitness - physiology</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Respiratory Physiological Phenomena</subject><subject>Tissue Plasminogen Activator - blood</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt-K1DAUxoso7rj6CEoQFAWnJumkTW8UGR1dmEXRFS9D_pxium0yJhmhj-EbmzJlhb3xKuTkd75zcr5TFI8JLgkm9eu-lGOvZTAlxZiXmJWY0DvFivCmXZOWVHeLFcaYrluyac-KBzH2-UoIq-8XZxlqqrYlq-LPVxhkst4h36FtlrM-QDzYIJMPE9rZ5CBGlDy6cN0gx_EUv5ThGkJ8lQEVrPPDlKxGO6nza45KZ9DeHvwh-ATWvZAvkXXoSy4ELkX0w6af6Go6AKLovZUKEkR0CcNg0zE-LO51cojwaDnPi--7D1fbT-v9548X23f7td40LK1BScVkbRThhtVyY3jLKO5MjRU3FSNdqzaGZKYlGja6451URFPVVJxVDW-q8-L5STc3-esIMYnRRp2bkA78MYp61msIyeDTW2Dvj8Hl3gStcNVQzmY1doJ08DEG6MQh2FGGSRAsZsNELxbDxGyYwExkw3Lek0X8qEYw_7IWhzLwbAFk1HLognTaxhuO4prjGteZe3viIM_st4Ugos7T1mBsAJ2E8fa_rby5paAH62wueg0TxJtPExGpwOLbvF3zcmGeRSpOq7-sYM0S</recordid><startdate>20080915</startdate><enddate>20080915</enddate><creator>Jae, Sae Young, PhD</creator><creator>Heffernan, Kevin S., MS</creator><creator>Lee, Moon-Kyu, MD</creator><creator>Fernhall, Bo, PhD</creator><creator>Park, Won Hah, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080915</creationdate><title>Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus</title><author>Jae, Sae Young, PhD ; Heffernan, Kevin S., MS ; Lee, Moon-Kyu, MD ; Fernhall, Bo, PhD ; Park, Won Hah, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-ebab5a6db18d56a4d89520fd60b8d351f9b4d1ab591ce4cf8fab1c2b738537873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Body Fat Distribution</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Physiological Phenomena</topic><topic>Cholesterol - blood</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Exercise Test</topic><topic>Fibrinogen - analysis</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Fitness - physiology</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Respiratory Physiological Phenomena</topic><topic>Tissue Plasminogen Activator - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jae, Sae Young, PhD</creatorcontrib><creatorcontrib>Heffernan, Kevin S., MS</creatorcontrib><creatorcontrib>Lee, Moon-Kyu, MD</creatorcontrib><creatorcontrib>Fernhall, Bo, PhD</creatorcontrib><creatorcontrib>Park, Won Hah, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jae, Sae Young, PhD</au><au>Heffernan, Kevin S., MS</au><au>Lee, Moon-Kyu, MD</au><au>Fernhall, Bo, PhD</au><au>Park, Won Hah, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2008-09-15</date><risdate>2008</risdate><volume>102</volume><issue>6</issue><spage>700</spage><epage>703</epage><pages>700-703</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract><![CDATA[Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p <0.05), white blood cell count (r = −0.13, p <0.05), fibrinogen (r = −0.28, p <0.05), LP(a) (r = −0.53, p <0.05), tissue plasminogen activator (t-PA) antigen (r = −0.65, p <0.05), and plasminogen activator inhibitor-1 activity (r = −0.17, p <0.05). Men in the highest tertile of CRF had significantly lower CRP, white blood cell count, fibrinogen, LP(a), and t-PA than men in the lowest tertile of CRF (all p <0.05). In separate multivariable linear regression models that adjusted for age, body mass index, smoking, lipid profiles, glucose, and systolic blood pressure, CRP (β = −0.23, p <0.05), white blood cell count (β = −0.16, p <0.05), fibrinogen (β = −0.24, p <0.05), LP(a) (β = −0.28, p <0.05), and t-PA (β = −0.69, p <0.05) were each inversely associated with CRF. Each MET increment higher peak oxygen uptake was associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95% confidence interval 0.20 to 0.91) in a multivariate logistic regression model. In conclusion, CRF was inversely associated with inflammatory markers, fibrinolytic factors, and LP(a) in men with type 2 diabetes.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18773991</pmid><doi>10.1016/j.amjcard.2008.05.012</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Factors Biological and medical sciences Biomarkers - blood Body Fat Distribution C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular Physiological Phenomena Cholesterol - blood Correlation analysis Diabetes Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Test Fibrinogen - analysis Humans Leukocyte Count Leukocytes Lipoprotein(a) - blood Male Medical sciences Medical screening Middle Aged Mortality Oxygen Consumption - physiology Physical Fitness - physiology Plasminogen Activator Inhibitor 1 - blood Proteins Regression analysis Respiratory Physiological Phenomena Tissue Plasminogen Activator - blood |
| title | Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus |
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