Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus

Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is...

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Veröffentlicht in:	The American journal of cardiology 2008-09, Vol.102 (6), p.700-703
Hauptverfasser:	Jae, Sae Young, PhD, Heffernan, Kevin S., MS, Lee, Moon-Kyu, MD, Fernhall, Bo, PhD, Park, Won Hah, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Biological and medical sciences Biomarkers - blood Body Fat Distribution C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular Physiological Phenomena Cholesterol - blood Correlation analysis Diabetes Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Exercise Test Fibrinogen - analysis Humans Leukocyte Count Leukocytes Lipoprotein(a) - blood Male Medical sciences Medical screening Middle Aged Mortality Oxygen Consumption - physiology Physical Fitness - physiology Plasminogen Activator Inhibitor 1 - blood Proteins Regression analysis Respiratory Physiological Phenomena Tissue Plasminogen Activator - blood
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Zusammenfassung:	Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP[a]) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2008.05.012