Appraisal of sickle-cell and thalassaemia genes in Saudi Arabia

Appraisal of sickle-cell and thalassaemia genes in Saudi Arabia

A comprehensive national survey of the distribution of the sickle-cell (Hb S) gene and thalassaemia genes was initiated in 1982, with more than 30,055 blood samples collected. The Hb S, alpha- and beta-thalassaemia gene frequency range was 0.005-0.145, 0.01-0.40 and 0.01-0.15 respectively in various...

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Veröffentlicht in:Eastern Mediterranean health journal 1999-11, Vol.5 (6), p.1147-1153
Hauptverfasser: el-Hazmi, M A, Warsy, A S
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
alpha-Thalassemia - epidemiology
alpha-Thalassemia - genetics
Anemia, Sickle Cell - epidemiology
Anemia, Sickle Cell - genetics
beta-Thalassemia - epidemiology
beta-Thalassemia - genetics
Child
Child, Preschool
Female
Gene Deletion
Gene Expression Regulation - genetics
Gene Frequency - genetics
Genetic Testing
Humans
Male
Middle Aged
Mutation - genetics
Phenotype
Population Surveillance
Prevalence
Residence Characteristics - statistics & numerical data
Saudi Arabia - epidemiology
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Zusammenfassung:A comprehensive national survey of the distribution of the sickle-cell (Hb S) gene and thalassaemia genes was initiated in 1982, with more than 30,055 blood samples collected. The Hb S, alpha- and beta-thalassaemia gene frequency range was 0.005-0.145, 0.01-0.40 and 0.01-0.15 respectively in various areas of Saudi Arabia. We present here an appraisal of sickle-cell and thalassaemia gene occurrence in the Saudi population, based on our studies conducted over 10 years in different regions of Saudi Arabia.
ISSN:1020-3397
1687-1634
DOI:10.26719/1999.5.6.1147