Pestalachlorides A–C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

Pestalachlorides A–C ( 1– 3), three new chlorinated benzophenones, have been isolated from the plant endophyte Pestalotiopsis adusta and evaluated for their antifungal activities. Pestalachlorides A–C ( 1– 3), three new chlorinated benzophenone derivatives, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis adusta. The structures of these compounds were determined mainly by NMR spectroscopy, and the structures of 1 and 3 were further confirmed by X-ray crystallography. Pestalachloride A ( 1) was obtained as a mixture of two inseparable atropisomers ( 1a and 1b), whereas pestalachloride C ( 3) was found to be a racemic mixture. Compounds 1 and 2 displayed significant antifungal activities against three plant pathogens.