On the formation of steroidal amidoesters of 4-[N,N-bis(2-chloroethyl)amino]benzoic acid and their cytotoxic activity
The 4-[N,N-bis(2-chloroethyl)amino]benzoate of 17β-acetamido-5α-androstan-3β-ol, 17β-acetamido-5-androsten-3β-ol, 3β-acetamido-5α-androstan-17β-ol and 3α-acetamido-5β-androstan-17β-ol have been prepared and their antineoplastic effect evaluated against MIA Pa-Ca-2 pancreatic carcinoma, T47D breast c...
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Veröffentlicht in: | European journal of medicinal chemistry 1999-07, Vol.34 (7), p.645-649 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The 4-[N,N-bis(2-chloroethyl)amino]benzoate of 17β-acetamido-5α-androstan-3β-ol, 17β-acetamido-5-androsten-3β-ol, 3β-acetamido-5α-androstan-17β-ol and 3α-acetamido-5β-androstan-17β-ol have been prepared and their antineoplastic effect evaluated against MIA Pa-Ca-2 pancreatic carcinoma, T47D breast carcinoma and A431 squamus cell carcinoma. Among the compounds tested, the compound 17β-acetamido-3β-hydroxy-5-androsten-4-[N, N-bis(2-chloroethyl)amino]benzoate appeared to possess a significant cytotoxic effect against A431 cells. |
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ISSN: | 0223-5234 1768-3254 |
DOI: | 10.1016/S0223-5234(00)80033-1 |