Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)
Abstract Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope10 B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a7 Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately...
Gespeichert in:
| Veröffentlicht in: | Critical reviews in oncology/hematology 2008-10, Vol.68 (1), p.66-90 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 1 |
| container_start_page | 66 |
| container_title | Critical reviews in oncology/hematology |
| container_volume | 68 |
| creator | Wittig, Andrea Michel, Jean Moss, Raymond L Stecher-Rasmussen, Finn Arlinghaus, Heinrich F Bendel, Peter Mauri, Pier Luigi Altieri, Saverio Hilger, Ralf Salvadori, Piero A Menichetti, Luca Zamenhof, Robert Sauerwein, Wolfgang A.G |
| description | Abstract Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope10 B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a7 Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of10 B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of10 B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality. |
| doi_str_mv | 10.1016/j.critrevonc.2008.03.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69493604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1040842808000565</els_id><sourcerecordid>69493604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-98c64d85cc52fee312c71c5546dda0acf35f7bcc6ed31f0f39540d27ec0f5b423</originalsourceid><addsrcrecordid>eNqNkU9r3DAQxU1padKkX6HoVNqD3ZEly_Kl0F36D0JyyPYs5PF4q63X2kp2YL995OxCoKeeZhh-b4Z5L8sYh4IDV592BQY3BXrwIxYlgC5AFADyRXbJdd3kIBV_mXqQkGtZ6ovsTYw7SIRU9evsgmspGi3UZWZXPviR2dEOx-hiajrWPo3c3m7duGVuZK3zg986tAPb24mCs0NkvQ_sJL6leVrq2h6mORDb_KZgD0f2YXW73ny8zl71iae353qV_fr2dbP-kd_cff-5_nKToyzrKW80KtnpCrEqeyLBS6w5VpVUXWfBYi-qvm4RFXWC99CLppLQlTUh9FUrS3GVvT_tPQT_d6Y4mb2LSMNgR_JzNKqRjVAgE6hPIAYfY6DeHEJ6NhwNB7PYa3bm2V6z2GtAGHiSvjvfmNs9dc_Cs58JWJ0ASp8-OAomoqMRqXOBcDKdd_9z5fM_S3Bw42L_HzpS3Pk5pLii4SaWBsz9EvOSMuiUcKUq8Qh2aKbc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69493604</pqid></control><display><type>article</type><title>Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Wittig, Andrea ; Michel, Jean ; Moss, Raymond L ; Stecher-Rasmussen, Finn ; Arlinghaus, Heinrich F ; Bendel, Peter ; Mauri, Pier Luigi ; Altieri, Saverio ; Hilger, Ralf ; Salvadori, Piero A ; Menichetti, Luca ; Zamenhof, Robert ; Sauerwein, Wolfgang A.G</creator><creatorcontrib>Wittig, Andrea ; Michel, Jean ; Moss, Raymond L ; Stecher-Rasmussen, Finn ; Arlinghaus, Heinrich F ; Bendel, Peter ; Mauri, Pier Luigi ; Altieri, Saverio ; Hilger, Ralf ; Salvadori, Piero A ; Menichetti, Luca ; Zamenhof, Robert ; Sauerwein, Wolfgang A.G</creatorcontrib><description>Abstract Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope10 B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a7 Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of10 B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of10 B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.</description><identifier>ISSN: 1040-8428</identifier><identifier>EISSN: 1879-0461</identifier><identifier>DOI: 10.1016/j.critrevonc.2008.03.004</identifier><identifier>PMID: 18439836</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Autoradiography ; Boron - metabolism ; Boron Neutron Capture Therapy ; Electron Energy Loss Spectroscopy ; Hematology, Oncology and Palliative Medicine ; Humans ; Inductively Coupled Plasma Mass Spectroscopy ; Ion Trap Mass Spectrometry ; Isotopes ; laser-SNMS ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Neoplasms - metabolism ; Neoplasms - pathology ; Neoplasms - radiotherapy ; Neutron Capture Radiography ; Nuclear Magnetic Resonance ; Positron Emission Tomography ; Prompt Gamma-ray Spectroscopy ; Radiobiology - methods ; Spectrometry, Gamma ; Spectrophotometry, Atomic ; Spectroscopy, Electron Energy-Loss ; Tissue Distribution</subject><ispartof>Critical reviews in oncology/hematology, 2008-10, Vol.68 (1), p.66-90</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-98c64d85cc52fee312c71c5546dda0acf35f7bcc6ed31f0f39540d27ec0f5b423</citedby><cites>FETCH-LOGICAL-c427t-98c64d85cc52fee312c71c5546dda0acf35f7bcc6ed31f0f39540d27ec0f5b423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.critrevonc.2008.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18439836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wittig, Andrea</creatorcontrib><creatorcontrib>Michel, Jean</creatorcontrib><creatorcontrib>Moss, Raymond L</creatorcontrib><creatorcontrib>Stecher-Rasmussen, Finn</creatorcontrib><creatorcontrib>Arlinghaus, Heinrich F</creatorcontrib><creatorcontrib>Bendel, Peter</creatorcontrib><creatorcontrib>Mauri, Pier Luigi</creatorcontrib><creatorcontrib>Altieri, Saverio</creatorcontrib><creatorcontrib>Hilger, Ralf</creatorcontrib><creatorcontrib>Salvadori, Piero A</creatorcontrib><creatorcontrib>Menichetti, Luca</creatorcontrib><creatorcontrib>Zamenhof, Robert</creatorcontrib><creatorcontrib>Sauerwein, Wolfgang A.G</creatorcontrib><title>Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)</title><title>Critical reviews in oncology/hematology</title><addtitle>Crit Rev Oncol Hematol</addtitle><description>Abstract Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope10 B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a7 Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of10 B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of10 B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.</description><subject>Autoradiography</subject><subject>Boron - metabolism</subject><subject>Boron Neutron Capture Therapy</subject><subject>Electron Energy Loss Spectroscopy</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Inductively Coupled Plasma Mass Spectroscopy</subject><subject>Ion Trap Mass Spectrometry</subject><subject>Isotopes</subject><subject>laser-SNMS</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - radiotherapy</subject><subject>Neutron Capture Radiography</subject><subject>Nuclear Magnetic Resonance</subject><subject>Positron Emission Tomography</subject><subject>Prompt Gamma-ray Spectroscopy</subject><subject>Radiobiology - methods</subject><subject>Spectrometry, Gamma</subject><subject>Spectrophotometry, Atomic</subject><subject>Spectroscopy, Electron Energy-Loss</subject><subject>Tissue Distribution</subject><issn>1040-8428</issn><issn>1879-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9r3DAQxU1padKkX6HoVNqD3ZEly_Kl0F36D0JyyPYs5PF4q63X2kp2YL995OxCoKeeZhh-b4Z5L8sYh4IDV592BQY3BXrwIxYlgC5AFADyRXbJdd3kIBV_mXqQkGtZ6ovsTYw7SIRU9evsgmspGi3UZWZXPviR2dEOx-hiajrWPo3c3m7duGVuZK3zg986tAPb24mCs0NkvQ_sJL6leVrq2h6mORDb_KZgD0f2YXW73ny8zl71iae353qV_fr2dbP-kd_cff-5_nKToyzrKW80KtnpCrEqeyLBS6w5VpVUXWfBYi-qvm4RFXWC99CLppLQlTUh9FUrS3GVvT_tPQT_d6Y4mb2LSMNgR_JzNKqRjVAgE6hPIAYfY6DeHEJ6NhwNB7PYa3bm2V6z2GtAGHiSvjvfmNs9dc_Cs58JWJ0ASp8-OAomoqMRqXOBcDKdd_9z5fM_S3Bw42L_HzpS3Pk5pLii4SaWBsz9EvOSMuiUcKUq8Qh2aKbc</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Wittig, Andrea</creator><creator>Michel, Jean</creator><creator>Moss, Raymond L</creator><creator>Stecher-Rasmussen, Finn</creator><creator>Arlinghaus, Heinrich F</creator><creator>Bendel, Peter</creator><creator>Mauri, Pier Luigi</creator><creator>Altieri, Saverio</creator><creator>Hilger, Ralf</creator><creator>Salvadori, Piero A</creator><creator>Menichetti, Luca</creator><creator>Zamenhof, Robert</creator><creator>Sauerwein, Wolfgang A.G</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)</title><author>Wittig, Andrea ; Michel, Jean ; Moss, Raymond L ; Stecher-Rasmussen, Finn ; Arlinghaus, Heinrich F ; Bendel, Peter ; Mauri, Pier Luigi ; Altieri, Saverio ; Hilger, Ralf ; Salvadori, Piero A ; Menichetti, Luca ; Zamenhof, Robert ; Sauerwein, Wolfgang A.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-98c64d85cc52fee312c71c5546dda0acf35f7bcc6ed31f0f39540d27ec0f5b423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Autoradiography</topic><topic>Boron - metabolism</topic><topic>Boron Neutron Capture Therapy</topic><topic>Electron Energy Loss Spectroscopy</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Inductively Coupled Plasma Mass Spectroscopy</topic><topic>Ion Trap Mass Spectrometry</topic><topic>Isotopes</topic><topic>laser-SNMS</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - radiotherapy</topic><topic>Neutron Capture Radiography</topic><topic>Nuclear Magnetic Resonance</topic><topic>Positron Emission Tomography</topic><topic>Prompt Gamma-ray Spectroscopy</topic><topic>Radiobiology - methods</topic><topic>Spectrometry, Gamma</topic><topic>Spectrophotometry, Atomic</topic><topic>Spectroscopy, Electron Energy-Loss</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wittig, Andrea</creatorcontrib><creatorcontrib>Michel, Jean</creatorcontrib><creatorcontrib>Moss, Raymond L</creatorcontrib><creatorcontrib>Stecher-Rasmussen, Finn</creatorcontrib><creatorcontrib>Arlinghaus, Heinrich F</creatorcontrib><creatorcontrib>Bendel, Peter</creatorcontrib><creatorcontrib>Mauri, Pier Luigi</creatorcontrib><creatorcontrib>Altieri, Saverio</creatorcontrib><creatorcontrib>Hilger, Ralf</creatorcontrib><creatorcontrib>Salvadori, Piero A</creatorcontrib><creatorcontrib>Menichetti, Luca</creatorcontrib><creatorcontrib>Zamenhof, Robert</creatorcontrib><creatorcontrib>Sauerwein, Wolfgang A.G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in oncology/hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wittig, Andrea</au><au>Michel, Jean</au><au>Moss, Raymond L</au><au>Stecher-Rasmussen, Finn</au><au>Arlinghaus, Heinrich F</au><au>Bendel, Peter</au><au>Mauri, Pier Luigi</au><au>Altieri, Saverio</au><au>Hilger, Ralf</au><au>Salvadori, Piero A</au><au>Menichetti, Luca</au><au>Zamenhof, Robert</au><au>Sauerwein, Wolfgang A.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)</atitle><jtitle>Critical reviews in oncology/hematology</jtitle><addtitle>Crit Rev Oncol Hematol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>68</volume><issue>1</issue><spage>66</spage><epage>90</epage><pages>66-90</pages><issn>1040-8428</issn><eissn>1879-0461</eissn><abstract>Abstract Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope10 B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a7 Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of10 B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of10 B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>18439836</pmid><doi>10.1016/j.critrevonc.2008.03.004</doi><tpages>25</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1040-8428 |
| ispartof | Critical reviews in oncology/hematology, 2008-10, Vol.68 (1), p.66-90 |
| issn | 1040-8428 1879-0461 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69493604 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Autoradiography Boron - metabolism Boron Neutron Capture Therapy Electron Energy Loss Spectroscopy Hematology, Oncology and Palliative Medicine Humans Inductively Coupled Plasma Mass Spectroscopy Ion Trap Mass Spectrometry Isotopes laser-SNMS Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mass Spectrometry Neoplasms - metabolism Neoplasms - pathology Neoplasms - radiotherapy Neutron Capture Radiography Nuclear Magnetic Resonance Positron Emission Tomography Prompt Gamma-ray Spectroscopy Radiobiology - methods Spectrometry, Gamma Spectrophotometry, Atomic Spectroscopy, Electron Energy-Loss Tissue Distribution |
| title | Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T16%3A15%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Boron%20analysis%20and%20boron%20imaging%20in%20biological%20materials%20for%20Boron%20Neutron%20Capture%20Therapy%20(BNCT)&rft.jtitle=Critical%20reviews%20in%20oncology/hematology&rft.au=Wittig,%20Andrea&rft.date=2008-10-01&rft.volume=68&rft.issue=1&rft.spage=66&rft.epage=90&rft.pages=66-90&rft.issn=1040-8428&rft.eissn=1879-0461&rft_id=info:doi/10.1016/j.critrevonc.2008.03.004&rft_dat=%3Cproquest_cross%3E69493604%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69493604&rft_id=info:pmid/18439836&rft_els_id=1_s2_0_S1040842808000565&rfr_iscdi=true |