Bipleiophylline, an Unprecedented Cytotoxic Bisindole Alkaloid Constituted from the Bridging of Two Indole Moieties by an Aromatic Spacer Unit

A cytotoxic bisindole alkaloid possessing an unprecedented structure in which two indole moieties are bridged by an aromatic spacer unit has been isolated from Alstonia angustifolia. The structure was established by analysis of the spectroscopic data and confirmed by X-ray diffraction analysis. A po...

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Veröffentlicht in:	Organic letters 2008-09, Vol.10 (17), p.3749-3752
Hauptverfasser:	Kam, Toh-Seok, Tan, Shin-Jowl, Ng, Seik-Weng, Komiyama, Kanki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alstonia - chemistry Humans Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Jurkat Cells KB Cells Models, Molecular Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Bark - chemistry Spectrophotometry, Infrared Spectrophotometry, Ultraviolet X-Ray Diffraction
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Beschreibung
Zusammenfassung:	A cytotoxic bisindole alkaloid possessing an unprecedented structure in which two indole moieties are bridged by an aromatic spacer unit has been isolated from Alstonia angustifolia. The structure was established by analysis of the spectroscopic data and confirmed by X-ray diffraction analysis. A possible biogenetic pathway from pyrocatechuic acid and pleiocarpamine is presented.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol801354s