Chromofluorescent Indicator for Intracellular Zn2+/Hg2+ Dynamic Exchange

Chromofluorescent Indicator for Intracellular Zn2+/Hg2+ Dynamic Exchange

The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ−Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg2+. This results in the concomitant export of Hg2+ from the cells, showing that NABQ can act as a Zn2+ c...

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Veröffentlicht in:Organic letters 2008-09, Vol.10 (17), p.3801-3804
Hauptverfasser: Lee, Jeong Won, Jung, Hyo Sung, Kwon, Pil Seung, Kim, Jong Wan, Bartsch, Richard A, Kim, Youngmee, Kim, Sung-Jin, Kim, Jong Seung
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Benzenesulfonamides
Cations, Divalent - chemistry
Cell Line
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Humans
Mercury - analysis
Mercury - chemistry
Mercury - metabolism
Quinaldines - chemical synthesis
Quinaldines - chemistry
Spectrometry, Fluorescence - methods
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Zinc - analysis
Zinc - chemistry
Zinc - metabolism
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Zusammenfassung:The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ−Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg2+. This results in the concomitant export of Hg2+ from the cells, showing that NABQ can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol801482n