Clinical resolution of glycogenic hepatopathy following improved glycemic control

Abstract Glycogenic hepatopathy is an underrecognized complication of long-standing poorly controlled diabetes mellitus. It is characterized by abnormal glycogen accumulation in hepatocytes, elevated liver enzymes and hepatomegaly. This is a distinct entity from other causes of hepatomegaly and elev...

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Veröffentlicht in:	Journal of diabetes and its complications 2008-09, Vol.22 (5), p.329-330
Hauptverfasser:	Hudacko, Rachel M, Manoukian, Aram V, Schneider, Stephen H, Fyfe, Billie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biopsy Blood Glucose - drug effects Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - pathology Disease Endocrinology & Metabolism Female Glycogen Glycogen Storage Disease - drug therapy Glycogen Storage Disease - etiology Glycogen Storage Disease - pathology Glycogenosis Hepatomegaly Humans Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Liver diseases Liver Diseases - drug therapy Liver Diseases - etiology Liver Diseases - pathology Treatment Outcome
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Zusammenfassung:	Abstract Glycogenic hepatopathy is an underrecognized complication of long-standing poorly controlled diabetes mellitus. It is characterized by abnormal glycogen accumulation in hepatocytes, elevated liver enzymes and hepatomegaly. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics such as nonalcoholic fatty liver disease. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control as described by this case report.
ISSN:	1056-8727 1873-460X
DOI:	10.1016/j.jdiacomp.2007.11.004