Promiscuous Watson-Crick cross-pairing within the family of pentopyranosyl (4'-->2') oligonucleotides

Promiscuous Watson-Crick cross-pairing within the family of pentopyranosyl (4'-->2') oligonucleotides

[formula: see text] The D-beta-ribo, D-beta-xylo, L-alpha-lyxo, and L-alpha-arabino members of the pentopyranosyl (4'-->2') oligonucleotide family show efficient intersystem cross-pairing among each other. This family of configurationally isomeric and conformationally well-defined pairi...

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Veröffentlicht in:Organic letters 1999-11, Vol.1 (10), p.1527-1530
Hauptverfasser: Jungmann, O, Wippo, H, Stanek, M, Huynh, H K, Krishnamurthy, R, Eschenmoser, A
Format: Artikel
Sprache:eng
Schlagworte:
Base Pairing
Nucleic Acid Conformation
Oligonucleotides - chemistry
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Zusammenfassung:[formula: see text] The D-beta-ribo, D-beta-xylo, L-alpha-lyxo, and L-alpha-arabino members of the pentopyranosyl (4'-->2') oligonucleotide family show efficient intersystem cross-pairing among each other. This family of configurationally isomeric and conformationally well-defined pairing systems offers an opportunity to study structural factors that determine cross-communication between informational oligonucleotide systems of different backbone structure.
ISSN:1523-7060
DOI:10.1021/ol990183y