Increased expression of hepatic DNA methyltransferase in smokers
The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation...
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| Veröffentlicht in: | Cell biology and toxicology 1999-01, Vol.15 (6), p.389-394 |
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| creator | HAMMONS, G. J YAN, Y LOPATINA, N. G JIN, B WISE, C BLANN, E. B POIRIER, L. A KADLUBAR, F. F LYN-COOK, B. D |
| description | The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation and promotion of cancer. This study was conducted to assess whether cigarette smoking and other factors, such as age and gender, influence DNA MTase expression in nontumorous tissue. DNA MTase was significantly (p |
| doi_str_mv | 10.1023/a:1007658000971 |
| format | Article |
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J ; YAN, Y ; LOPATINA, N. G ; JIN, B ; WISE, C ; BLANN, E. B ; POIRIER, L. A ; KADLUBAR, F. F ; LYN-COOK, B. D</creator><contributor>Batt, A-M ; Ferrari, L</contributor><creatorcontrib>HAMMONS, G. J ; YAN, Y ; LOPATINA, N. G ; JIN, B ; WISE, C ; BLANN, E. B ; POIRIER, L. A ; KADLUBAR, F. F ; LYN-COOK, B. D ; Batt, A-M ; Ferrari, L</creatorcontrib><description>The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation and promotion of cancer. This study was conducted to assess whether cigarette smoking and other factors, such as age and gender, influence DNA MTase expression in nontumorous tissue. DNA MTase was significantly (p<0.05) higher in samples from cigarette smokers; the mean level of DNA MTase mRNA was almost 2-fold higher in these samples than in those from nonsmokers. Levels of DNA MTase mRNA were higher in samples from females than in those from males, but the difference was not statistically significant. Age was not associated with DNA MTase levels. Increased levels of DNA MTase in individuals who smoke may indicate a greater susceptibility to the risk of cancer since increased levels of this enzyme are found in cancer cell lines and human tumors. The results of this study suggest that further investigations of increased expression of this enzyme as a predisposing factor for cancer susceptibility are needed.</description><identifier>ISSN: 0742-2091</identifier><identifier>EISSN: 1573-6822</identifier><identifier>DOI: 10.1023/a:1007658000971</identifier><identifier>PMID: 10811534</identifier><identifier>CODEN: CBTOE2</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Base Sequence ; Biological and medical sciences ; Cancer ; Cigarettes ; Deoxyribonucleic acid ; DNA ; DNA methylation ; DNA Primers ; DNA-Cytosine Methylases - genetics ; Female ; Health risks ; Humans ; Liver - enzymology ; Male ; Medical sciences ; Middle Aged ; RNA, Messenger - genetics ; Sex Factors ; Smoking - metabolism ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Cell biology and toxicology, 1999-01, Vol.15 (6), p.389-394</ispartof><rights>2000 INIST-CNRS</rights><rights>Kluwer Academic Publishers 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-177384e976abb741a0018d4727fbf3bc6879edc5c26c99bfd418ffc1f142cf623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1391725$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10811534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Batt, A-M</contributor><contributor>Ferrari, L</contributor><creatorcontrib>HAMMONS, G. J</creatorcontrib><creatorcontrib>YAN, Y</creatorcontrib><creatorcontrib>LOPATINA, N. G</creatorcontrib><creatorcontrib>JIN, B</creatorcontrib><creatorcontrib>WISE, C</creatorcontrib><creatorcontrib>BLANN, E. B</creatorcontrib><creatorcontrib>POIRIER, L. A</creatorcontrib><creatorcontrib>KADLUBAR, F. F</creatorcontrib><creatorcontrib>LYN-COOK, B. D</creatorcontrib><title>Increased expression of hepatic DNA methyltransferase in smokers</title><title>Cell biology and toxicology</title><addtitle>Cell Biol Toxicol</addtitle><description>The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation and promotion of cancer. This study was conducted to assess whether cigarette smoking and other factors, such as age and gender, influence DNA MTase expression in nontumorous tissue. DNA MTase was significantly (p<0.05) higher in samples from cigarette smokers; the mean level of DNA MTase mRNA was almost 2-fold higher in these samples than in those from nonsmokers. Levels of DNA MTase mRNA were higher in samples from females than in those from males, but the difference was not statistically significant. Age was not associated with DNA MTase levels. Increased levels of DNA MTase in individuals who smoke may indicate a greater susceptibility to the risk of cancer since increased levels of this enzyme are found in cancer cell lines and human tumors. The results of this study suggest that further investigations of increased expression of this enzyme as a predisposing factor for cancer susceptibility are needed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cigarettes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA Primers</subject><subject>DNA-Cytosine Methylases - genetics</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>RNA, Messenger - genetics</subject><subject>Sex Factors</subject><subject>Smoking - metabolism</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0742-2091</issn><issn>1573-6822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0EtLAzEUhuEgiq3VtTsZRNyN5iSZXFxZ6q1QdKPrIZNJ6NS5mcyA_fcGrAhuXJ3Nw4HvRegU8BVgQq_1DWAseCYxxkrAHppCJmjKJSH7aIoFIynBCiboKIRNNBxEdogmgCVARtkU3S5b460OtkzsZ-9tCFXXJp1L1rbXQ2WSu-d50thhva0Hr9vgrI84qdokNN279eEYHThdB3uyuzP09nD_unhKVy-Py8V8lRqG-ZCCEFQyqwTXRSEYaIxBlkwQ4QpHC8OlULY0mSHcKFW4koF0zoADRozjhM7Q5fff3ncfow1D3lTB2LrWre3GkHPFBAXG_4WxAFVCyQjP_8BNN_o2jsgF44wRxnFEZzs0Fo0t895Xjfbb_KdgBBc7oIPRtYuRTBV-HVUgSEa_AODNffM</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>HAMMONS, G. 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J ; YAN, Y ; LOPATINA, N. G ; JIN, B ; WISE, C ; BLANN, E. B ; POIRIER, L. A ; KADLUBAR, F. F ; LYN-COOK, B. 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J</au><au>YAN, Y</au><au>LOPATINA, N. G</au><au>JIN, B</au><au>WISE, C</au><au>BLANN, E. B</au><au>POIRIER, L. A</au><au>KADLUBAR, F. F</au><au>LYN-COOK, B. D</au><au>Batt, A-M</au><au>Ferrari, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of hepatic DNA methyltransferase in smokers</atitle><jtitle>Cell biology and toxicology</jtitle><addtitle>Cell Biol Toxicol</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>15</volume><issue>6</issue><spage>389</spage><epage>394</epage><pages>389-394</pages><issn>0742-2091</issn><eissn>1573-6822</eissn><coden>CBTOE2</coden><abstract>The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation and promotion of cancer. This study was conducted to assess whether cigarette smoking and other factors, such as age and gender, influence DNA MTase expression in nontumorous tissue. DNA MTase was significantly (p<0.05) higher in samples from cigarette smokers; the mean level of DNA MTase mRNA was almost 2-fold higher in these samples than in those from nonsmokers. Levels of DNA MTase mRNA were higher in samples from females than in those from males, but the difference was not statistically significant. Age was not associated with DNA MTase levels. Increased levels of DNA MTase in individuals who smoke may indicate a greater susceptibility to the risk of cancer since increased levels of this enzyme are found in cancer cell lines and human tumors. The results of this study suggest that further investigations of increased expression of this enzyme as a predisposing factor for cancer susceptibility are needed.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>10811534</pmid><doi>10.1023/a:1007658000971</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Base Sequence Biological and medical sciences Cancer Cigarettes Deoxyribonucleic acid DNA DNA methylation DNA Primers DNA-Cytosine Methylases - genetics Female Health risks Humans Liver - enzymology Male Medical sciences Middle Aged RNA, Messenger - genetics Sex Factors Smoking - metabolism Tobacco, tobacco smoking Toxicology |
| title | Increased expression of hepatic DNA methyltransferase in smokers |
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