Increased expression of hepatic DNA methyltransferase in smokers

The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation...

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Veröffentlicht in:	Cell biology and toxicology 1999-01, Vol.15 (6), p.389-394
Hauptverfasser:	HAMMONS, G. J, YAN, Y, LOPATINA, N. G, JIN, B, WISE, C, BLANN, E. B, POIRIER, L. A, KADLUBAR, F. F, LYN-COOK, B. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Base Sequence Biological and medical sciences Cancer Cigarettes Deoxyribonucleic acid DNA DNA methylation DNA Primers DNA-Cytosine Methylases - genetics Female Health risks Humans Liver - enzymology Male Medical sciences Middle Aged RNA, Messenger - genetics Sex Factors Smoking - metabolism Tobacco, tobacco smoking Toxicology
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Zusammenfassung:	The DNA methyltransferase enzyme (DNA MTase) catalyzes DNA methylation at cytosines in CpG dinucleotides. 5-Methylcytosine modification of DNA is important in gene regulation, DNA replication, chromatin organization and disease. Increased levels of DNA MTase have been associated with the initiation and promotion of cancer. This study was conducted to assess whether cigarette smoking and other factors, such as age and gender, influence DNA MTase expression in nontumorous tissue. DNA MTase was significantly (p
ISSN:	0742-2091 1573-6822
DOI:	10.1023/a:1007658000971