Novel Strategies to Construct the γ-Hydroxy Lactone Moiety of the CP Molecules. Synthesis of the CP-225,917 Core Skeleton

The array of challenging structural lineaments embodied in the CP molecules (1 and 2, Figure ) offers synthetic chemists uncharted realms of exploration and discovery. In this communication, we focus on the chemical hurdles posed by the γ-hydroxy lactone moiety of these exciting targets. Thus, the examination of the general reactivity of these systems, the development of a novel tandem oxidation sequence to construct the γ-hydroxy lactone moiety, and the successful construction of the complete polycyclic core of 2 (compound 28, Scheme 5) is enumerated within.