Synthesis of Cyclic Oligopeptides Containing an Arg-Gly-Asp (RGD) Sequence

The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthsized by the solution method and their cyc...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1999/12/15, Vol.47(12), pp.1799-1801
Hauptverfasser:	SOFUKU, Shosuke, HOSHIDA, Akiko, SHIMADA, Takehiro, TAKADA, Yoichi, TAKAKUWA, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Arg-Gly-Asp (RGD) sequence Azides Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system circular dichroism spectrum cyclic peptide Cyclization Humans In Vitro Techniques Medical sciences Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Peptides, Cyclic - chemical synthesis Peptides, Cyclic - pharmacology Pharmacology. Drug treatments platelet aggregation inhibitor Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology Structure-Activity Relationship
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Zusammenfassung:	The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthsized by the solution method and their cyclization was performed in high dilution using DPPA.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.47.1799