Iron-Catalyst-Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ-Unsaturated Amides as Versatile Templates for Asymmetric Three-Component Coupling Processes
Diene for conjugate addition: Iron(II) chloride switches the reaction course of the three‐component coupling of a Grignard reagent, an alkyl halide, and a dienamide, thus making the amide a simple yet versatile chiral template.
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2008-08, Vol.47 (36), p.6860-6864 |
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| container_end_page | 6864 |
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| container_issue | 36 |
| container_start_page | 6860 |
| container_title | Angewandte Chemie (International ed.) |
| container_volume | 47 |
| creator | Okada, Satoshi Arayama, Kyohei Murayama, Ryuji Ishizuka, Takumi Hara, Keiichi Hirone, Naoki Hata, Takeshi Urabe, Hirokazu |
| description | Diene for conjugate addition: Iron(II) chloride switches the reaction course of the three‐component coupling of a Grignard reagent, an alkyl halide, and a dienamide, thus making the amide a simple yet versatile chiral template. |
| doi_str_mv | 10.1002/anie.200801928 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alkylation amides Amides - chemical synthesis asymmetric reaction Catalysis conjugate addition Grignard reagents iron Iron - chemistry |
| title | Iron-Catalyst-Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ-Unsaturated Amides as Versatile Templates for Asymmetric Three-Component Coupling Processes |
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