Iron-Catalyst-Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ-Unsaturated Amides as Versatile Templates for Asymmetric Three-Component Coupling Processes

Iron-Catalyst-Switched Selective Conjugate Addition of Grignard Reagents: α,β,γ,δ-Unsaturated Amides as Versatile Templates for Asymmetric Three-Component Coupling Processes

Diene for conjugate addition: Iron(II) chloride switches the reaction course of the three‐component coupling of a Grignard reagent, an alkyl halide, and a dienamide, thus making the amide a simple yet versatile chiral template.

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-08, Vol.47 (36), p.6860-6864
Hauptverfasser: Okada, Satoshi, Arayama, Kyohei, Murayama, Ryuji, Ishizuka, Takumi, Hara, Keiichi, Hirone, Naoki, Hata, Takeshi, Urabe, Hirokazu
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
amides
Amides - chemical synthesis
asymmetric reaction
Catalysis
conjugate addition
Grignard reagents
iron
Iron - chemistry
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Beschreibung
Zusammenfassung:Diene for conjugate addition: Iron(II) chloride switches the reaction course of the three‐component coupling of a Grignard reagent, an alkyl halide, and a dienamide, thus making the amide a simple yet versatile chiral template.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801928