Enantioselective C----H Amination Using Cationic Ruthenium(II)-pybox Catalysts

Enantioselective C----H Amination Using Cationic Ruthenium(II)-pybox Catalysts

The whole “pybox” and dice: Highly enantioselective amination reactions of both allylic and benzylic CH bonds are catalyzed by cationic ruthenium(II)–pybox complexes (see structure). A novel mode of stereocontrol, which is induced by the versatile pybox ligand, is proposed to account for the excell...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-08, Vol.47 (36), p.6825-6828
Hauptverfasser: Milczek, Erika, Boudet, Nadège, Blakey, Simon
Format: Artikel
Sprache:eng
Schlagworte:
amination
asymmetric catalysis
CH activation
ruthenium
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Zusammenfassung:The whole “pybox” and dice: Highly enantioselective amination reactions of both allylic and benzylic CH bonds are catalyzed by cationic ruthenium(II)–pybox complexes (see structure). A novel mode of stereocontrol, which is induced by the versatile pybox ligand, is proposed to account for the excellent enantioselectivity in these reactions. Boc=tert‐butoxycarbonyl, pybox=pyridine bisoxazoline.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801445