Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Abstract Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association w...

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Veröffentlicht in:	Cancer genetics and cytogenetics 2008-09, Vol.185 (2), p.95-101
Hauptverfasser:	Lau, Lai-Ching, Lim, Ping, Lim, Yik-Chen, Teng, Li-Min, Lim, Tse-Hui, Lim, Lay–Cheng, Tan, Soo-Yong, Lim, Soon-Tiong, Sanger, Warren G, Tien, Sim-Leng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Flow Cytometry Hematology, Oncology and Palliative Medicine Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Medical Education Middle Aged Translocation, Genetic Trisomy
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Zusammenfassung:	Abstract Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/j.cancergencyto.2008.04.017