Angioscopic Comparison of Neointimal Coverage Between Zotarolimus- and Sirolimus-Eluting Stents
Drug-eluting stents (DES) have demonstrated reduced late loss (LL) and low target lesion revascularization (TLR) rates through an inhibitory effect on neointimal hyperplasia but might have a risk of late or very late stent thrombosis due to incomplete neointimal coverage (NIC) (1-3). Considering the...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-08, Vol.52 (9), p.789-790 |
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| creator | Awata, Masaki, MD Nanto, Shinsuke, MD, PhD, FACC Uematsu, Masaaki, MD, PhD, FACC Morozumi, Takakazu, MD, PhD Watanabe, Tetsuya, MD, PhD Onishi, Toshinari, MD Iida, Osamu, MD Sera, Fusako, MD Kotani, Jun-ichi, MD, PhD, FACC Hori, Masatsugu, MD, PhD, FACC Nagata, Seiki, MD, PhD |
| description | Drug-eluting stents (DES) have demonstrated reduced late loss (LL) and low target lesion revascularization (TLR) rates through an inhibitory effect on neointimal hyperplasia but might have a risk of late or very late stent thrombosis due to incomplete neointimal coverage (NIC) (1-3). Considering the risk of stent thrombosis due to incomplete NIC, it is preferable for DES to have sufficient neointimal volume no greater than LL of 0.65 mm. Although the single-center, nonrandomized, matched-control, and observational nature with a small sample size of this study should be noted as a limitation, this study suggests that arterial endothelial healing after stenting is more competent in ZES than in SES. |
| doi_str_mv | 10.1016/j.jacc.2008.07.007 |
| format | Article |
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Considering the risk of stent thrombosis due to incomplete NIC, it is preferable for DES to have sufficient neointimal volume no greater than LL of 0.65 mm. Although the single-center, nonrandomized, matched-control, and observational nature with a small sample size of this study should be noted as a limitation, this study suggests that arterial endothelial healing after stenting is more competent in ZES than in SES.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2008.07.007</identifier><identifier>PMID: 18718430</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Angioplasty ; Angioscopy ; Blood clots ; Cardiology ; Cardiovascular ; Coronary Stenosis - pathology ; Coronary Stenosis - therapy ; Drug-Eluting Stents ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents - administration & dosage ; Internal Medicine ; Male ; Medical imaging ; Middle Aged ; Sirolimus - administration & dosage ; Sirolimus - analogs & derivatives ; Stents ; Thrombosis ; Tunica Intima</subject><ispartof>Journal of the American College of Cardiology, 2008-08, Vol.52 (9), p.789-790</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>Copyright Elsevier Limited Aug 26, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-dbf5a5bec2542ad4e00d70226439f3e264acc4c0a1a5a71e8fba80e7c64f81683</citedby><cites>FETCH-LOGICAL-c547t-dbf5a5bec2542ad4e00d70226439f3e264acc4c0a1a5a71e8fba80e7c64f81683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2008.07.007$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18718430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awata, Masaki, MD</creatorcontrib><creatorcontrib>Nanto, Shinsuke, MD, PhD, FACC</creatorcontrib><creatorcontrib>Uematsu, Masaaki, MD, PhD, FACC</creatorcontrib><creatorcontrib>Morozumi, Takakazu, MD, PhD</creatorcontrib><creatorcontrib>Watanabe, Tetsuya, MD, PhD</creatorcontrib><creatorcontrib>Onishi, Toshinari, MD</creatorcontrib><creatorcontrib>Iida, Osamu, MD</creatorcontrib><creatorcontrib>Sera, Fusako, MD</creatorcontrib><creatorcontrib>Kotani, Jun-ichi, MD, PhD, FACC</creatorcontrib><creatorcontrib>Hori, Masatsugu, MD, PhD, FACC</creatorcontrib><creatorcontrib>Nagata, Seiki, MD, PhD</creatorcontrib><title>Angioscopic Comparison of Neointimal Coverage Between Zotarolimus- and Sirolimus-Eluting Stents</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Drug-eluting stents (DES) have demonstrated reduced late loss (LL) and low target lesion revascularization (TLR) rates through an inhibitory effect on neointimal hyperplasia but might have a risk of late or very late stent thrombosis due to incomplete neointimal coverage (NIC) (1-3). Considering the risk of stent thrombosis due to incomplete NIC, it is preferable for DES to have sufficient neointimal volume no greater than LL of 0.65 mm. Although the single-center, nonrandomized, matched-control, and observational nature with a small sample size of this study should be noted as a limitation, this study suggests that arterial endothelial healing after stenting is more competent in ZES than in SES.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty</subject><subject>Angioscopy</subject><subject>Blood clots</subject><subject>Cardiology</subject><subject>Cardiovascular</subject><subject>Coronary Stenosis - pathology</subject><subject>Coronary Stenosis - therapy</subject><subject>Drug-Eluting Stents</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Sirolimus - administration & dosage</subject><subject>Sirolimus - analogs & derivatives</subject><subject>Stents</subject><subject>Thrombosis</subject><subject>Tunica Intima</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-L1DAQx4Mo3nr6D_ggBcG31knSNCmIcC7nDzj0YfXFl5BNp0tqm6xJe3L_vSm7cnAPPg1DPvMl8xlCXlKoKNDm7VANxtqKAagKZAUgH5ENFUKVXLTyMdmA5KKk0MoL8iylAQAaRdun5IIqSVXNYUP0lT-4kGw4Oltsw3Q00aXgi9AXXzE4P7vJjPnhFqM5YPEB5z-IvvgZZhPD6KYllYXxXbFz_9rrcZmdPxS7Gf2cnpMnvRkTvjjXS_Lj4_X37efy5tunL9urm9KKWs5lt--FEXu0TNTMdDUCdBIYa2re9hxzzZvWFgw1wkiKqt8bBShtU_eKNopfkjen3GMMvxdMs55csjiOxmNYkm7aWnDZruDrB-AQlujz3zQV0DBGWw6ZYifKxpBSxF4fYzYR7zQFvcrXg17l61W-Bqmz_Dz06hy97Cfs7kfOtjPw7gRgNnHrMOpkHXqLnYtoZ90F9__89w_G7ei8s2b8hXeY7vfQiWnQu_X86_VBAeOipvwvDQGq4A</recordid><startdate>20080826</startdate><enddate>20080826</enddate><creator>Awata, Masaki, MD</creator><creator>Nanto, Shinsuke, MD, PhD, FACC</creator><creator>Uematsu, Masaaki, MD, PhD, FACC</creator><creator>Morozumi, Takakazu, MD, PhD</creator><creator>Watanabe, Tetsuya, MD, PhD</creator><creator>Onishi, Toshinari, MD</creator><creator>Iida, Osamu, MD</creator><creator>Sera, Fusako, MD</creator><creator>Kotani, Jun-ichi, MD, PhD, FACC</creator><creator>Hori, Masatsugu, MD, PhD, FACC</creator><creator>Nagata, Seiki, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080826</creationdate><title>Angioscopic Comparison of Neointimal Coverage Between Zotarolimus- and Sirolimus-Eluting Stents</title><author>Awata, Masaki, MD ; 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Considering the risk of stent thrombosis due to incomplete NIC, it is preferable for DES to have sufficient neointimal volume no greater than LL of 0.65 mm. Although the single-center, nonrandomized, matched-control, and observational nature with a small sample size of this study should be noted as a limitation, this study suggests that arterial endothelial healing after stenting is more competent in ZES than in SES.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18718430</pmid><doi>10.1016/j.jacc.2008.07.007</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Angioplasty Angioscopy Blood clots Cardiology Cardiovascular Coronary Stenosis - pathology Coronary Stenosis - therapy Drug-Eluting Stents Female Follow-Up Studies Humans Immunosuppressive Agents - administration & dosage Internal Medicine Male Medical imaging Middle Aged Sirolimus - administration & dosage Sirolimus - analogs & derivatives Stents Thrombosis Tunica Intima |
| title | Angioscopic Comparison of Neointimal Coverage Between Zotarolimus- and Sirolimus-Eluting Stents |
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