Formation of hydroxyapatite coating using novel chemo-biomimetic method

A novel chemo-biomimetic method was developed to deposit hydroxyapatite (HA), simulating the porous nano-scale structure and chemical composition of natural bone. Electrochemical activation in NaOH solution, a prerequisite process to heterogeneously nucleate hydroxyapatite in this investigation, creates nano-scale porous structure on the surface of Ti6Al4V alloy. XPS analysis confirmed that the surface of activated Ti6Al4V substrate converted to TiO 2 during activation, existing in the form of hydrated TiO 2 . Benefiting from the biocompatible top-layer of hydrated TiO 2 and the favorable alkaline surface chemistry created through the electrochemical activation, the HA coating nucleates heterogeneously and grows continuously on the activated substrate resembling the nano-scale porous bone-like structure. The coating was characterized using XRD, SEM/FESEM/EDX, TEM and FTIR, and was confirmed as pure hydroxyapatite. A coating thickness of 50 μm was achieved, which is preferable and acceptable for medical implant application to promote bone ingrowth, thus enhancing fixation and biocompatibility of implant surface.