Total plasma homocysteine correlates in women with gestational diabetes
Aim We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM). Methods We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels we...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2008-10, Vol.278 (4), p.309-313 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Idzior-Waluś, B. Cyganek, K. Sztefko, K. Seghieri, G. Breschi, M. C. Waluś-Miarka, M. Kawalec, E. Seretny, M. Sieradzki, J. |
| description | Aim
We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM).
Methods
We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels were analyzed by ELISA, using Bio-Rad reagents. Serum folates and vitamin B
12
concentrations were determined by chemiluminescent immunoassay, free fatty acids (FFA) and lipids enzymatically.
Results
Serum homocysteine levels were similar in both the GDM and the CG groups (8 ± 2.0 vs 7.4 ± 1.1 μmol/l, respectively). Women with GDM in comparison to CG women were characterized by higher values of homeostasis model of insulin resistance (HOMA-IR) (2.8 ± 1.7 vs 1.6 ± 0.9,
P
|
| doi_str_mv | 10.1007/s00404-008-0571-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69448818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69448818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-5288732b720828daf3aeb4025a740875b688ee2c893815a803b7dbc7d7c51e763</originalsourceid><addsrcrecordid>eNp1kFFLwzAUhYMobk5_gC9SEHyr3qRNc_coQ6cw8GU-hzS92zraZiYd4r83o4OB4MvNhXzn3MNh7JbDIwdQTwEghzwFwBSk4ik_Y2OeZyIFxfk5G8P0sEOhRuwqhC0AF4jFJRtxFFkBUo7ZfOl60yS7xoTWJBvXOvsTeqo7SqzznhrTU0jqLvl2LcVZ95tkTaE3fe26KKxqU1JErtnFyjSBbo7vhH2-vixnb-niY_4-e16kNlPQpzIGUJkolQAUWJlVZqjMQUijckAlywKRSFicZsilQchKVZVWVcpKTqrIJuxh8N1597WPQXRbB0tNYzpy-6CLaZ4jcozg_R9w6_Y-Rg5aiIKjwkhGig-U9S4ETyu983Vr_I_moA8d66FjHTvWh441j5q7o_O-bKk6KY6lRkAMQIhf3Zr86fT_rr8Mb4Ww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261878944</pqid></control><display><type>article</type><title>Total plasma homocysteine correlates in women with gestational diabetes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Idzior-Waluś, B. ; Cyganek, K. ; Sztefko, K. ; Seghieri, G. ; Breschi, M. C. ; Waluś-Miarka, M. ; Kawalec, E. ; Seretny, M. ; Sieradzki, J.</creator><creatorcontrib>Idzior-Waluś, B. ; Cyganek, K. ; Sztefko, K. ; Seghieri, G. ; Breschi, M. C. ; Waluś-Miarka, M. ; Kawalec, E. ; Seretny, M. ; Sieradzki, J.</creatorcontrib><description><![CDATA[Aim
We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM).
Methods
We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels were analyzed by ELISA, using Bio-Rad reagents. Serum folates and vitamin B
12
concentrations were determined by chemiluminescent immunoassay, free fatty acids (FFA) and lipids enzymatically.
Results
Serum homocysteine levels were similar in both the GDM and the CG groups (8 ± 2.0 vs 7.4 ± 1.1 μmol/l, respectively). Women with GDM in comparison to CG women were characterized by higher values of homeostasis model of insulin resistance (HOMA-IR) (2.8 ± 1.7 vs 1.6 ± 0.9,
P
< 0.01), serum triglycerides (2.7 ± 0.9 vs 1.9 ± 0.5 mmol/l,
P
< 0.01) and FFA (0.6 ± 0.2 vs 0.46 ± 0.2 mmol/l,
P
< 0.05). In GDM women serum tHcy correlated with vitamin B
12
(
r
= −0.47,
P
< 0.01) and folates (
r
= −0.51,
P
< 0.001); in CG women with HOMA-IR, a marker of insulin resistance (
r
= −0.49,
P
< 0.05). In multiple regression analysis with serum tHcy as a dependent variable, folate and vitamin B
12
entered the analysis in GDM women (beta = −0.42 and −0.34, respectively,
P
< 0.05), whereas in CG cystatin C and HOMA-IR entered the analysis (
P
< 0.05).
Conclusions
In women with GDM, serum homocysteine is significantly associated with vitamin B
12
and folate levels, while in healthy pregnant women with HOMA-IR and with kidney function. The results suggest the importance of the B-group vitamins in regulation of serum tHcy levels in women with insulin resistance/gestational diabetes, what might be relevant in protection against pregnancy complications associated with elevated tHcy in GDM women.]]></description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-008-0571-1</identifier><identifier>PMID: 18236055</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Case-Control Studies ; Diabetes ; Diabetes, Gestational - blood ; Endocrinology ; Female ; Folic Acid - blood ; Gynecology ; Health risk assessment ; Homocysteine ; Homocysteine - blood ; Human Genetics ; Humans ; Insulin Resistance ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Original Article ; Pregnancy ; Vitamin B 12 - blood</subject><ispartof>Archives of gynecology and obstetrics, 2008-10, Vol.278 (4), p.309-313</ispartof><rights>Springer-Verlag 2008</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2008). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-5288732b720828daf3aeb4025a740875b688ee2c893815a803b7dbc7d7c51e763</citedby><cites>FETCH-LOGICAL-c370t-5288732b720828daf3aeb4025a740875b688ee2c893815a803b7dbc7d7c51e763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-008-0571-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-008-0571-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18236055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Idzior-Waluś, B.</creatorcontrib><creatorcontrib>Cyganek, K.</creatorcontrib><creatorcontrib>Sztefko, K.</creatorcontrib><creatorcontrib>Seghieri, G.</creatorcontrib><creatorcontrib>Breschi, M. C.</creatorcontrib><creatorcontrib>Waluś-Miarka, M.</creatorcontrib><creatorcontrib>Kawalec, E.</creatorcontrib><creatorcontrib>Seretny, M.</creatorcontrib><creatorcontrib>Sieradzki, J.</creatorcontrib><title>Total plasma homocysteine correlates in women with gestational diabetes</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description><![CDATA[Aim
We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM).
Methods
We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels were analyzed by ELISA, using Bio-Rad reagents. Serum folates and vitamin B
12
concentrations were determined by chemiluminescent immunoassay, free fatty acids (FFA) and lipids enzymatically.
Results
Serum homocysteine levels were similar in both the GDM and the CG groups (8 ± 2.0 vs 7.4 ± 1.1 μmol/l, respectively). Women with GDM in comparison to CG women were characterized by higher values of homeostasis model of insulin resistance (HOMA-IR) (2.8 ± 1.7 vs 1.6 ± 0.9,
P
< 0.01), serum triglycerides (2.7 ± 0.9 vs 1.9 ± 0.5 mmol/l,
P
< 0.01) and FFA (0.6 ± 0.2 vs 0.46 ± 0.2 mmol/l,
P
< 0.05). In GDM women serum tHcy correlated with vitamin B
12
(
r
= −0.47,
P
< 0.01) and folates (
r
= −0.51,
P
< 0.001); in CG women with HOMA-IR, a marker of insulin resistance (
r
= −0.49,
P
< 0.05). In multiple regression analysis with serum tHcy as a dependent variable, folate and vitamin B
12
entered the analysis in GDM women (beta = −0.42 and −0.34, respectively,
P
< 0.05), whereas in CG cystatin C and HOMA-IR entered the analysis (
P
< 0.05).
Conclusions
In women with GDM, serum homocysteine is significantly associated with vitamin B
12
and folate levels, while in healthy pregnant women with HOMA-IR and with kidney function. The results suggest the importance of the B-group vitamins in regulation of serum tHcy levels in women with insulin resistance/gestational diabetes, what might be relevant in protection against pregnancy complications associated with elevated tHcy in GDM women.]]></description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - blood</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original Article</subject><subject>Pregnancy</subject><subject>Vitamin B 12 - blood</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kFFLwzAUhYMobk5_gC9SEHyr3qRNc_coQ6cw8GU-hzS92zraZiYd4r83o4OB4MvNhXzn3MNh7JbDIwdQTwEghzwFwBSk4ik_Y2OeZyIFxfk5G8P0sEOhRuwqhC0AF4jFJRtxFFkBUo7ZfOl60yS7xoTWJBvXOvsTeqo7SqzznhrTU0jqLvl2LcVZ95tkTaE3fe26KKxqU1JErtnFyjSBbo7vhH2-vixnb-niY_4-e16kNlPQpzIGUJkolQAUWJlVZqjMQUijckAlywKRSFicZsilQchKVZVWVcpKTqrIJuxh8N1597WPQXRbB0tNYzpy-6CLaZ4jcozg_R9w6_Y-Rg5aiIKjwkhGig-U9S4ETyu983Vr_I_moA8d66FjHTvWh441j5q7o_O-bKk6KY6lRkAMQIhf3Zr86fT_rr8Mb4Ww</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Idzior-Waluś, B.</creator><creator>Cyganek, K.</creator><creator>Sztefko, K.</creator><creator>Seghieri, G.</creator><creator>Breschi, M. C.</creator><creator>Waluś-Miarka, M.</creator><creator>Kawalec, E.</creator><creator>Seretny, M.</creator><creator>Sieradzki, J.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Total plasma homocysteine correlates in women with gestational diabetes</title><author>Idzior-Waluś, B. ; Cyganek, K. ; Sztefko, K. ; Seghieri, G. ; Breschi, M. C. ; Waluś-Miarka, M. ; Kawalec, E. ; Seretny, M. ; Sieradzki, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-5288732b720828daf3aeb4025a740875b688ee2c893815a803b7dbc7d7c51e763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diabetes, Gestational - blood</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original Article</topic><topic>Pregnancy</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Idzior-Waluś, B.</creatorcontrib><creatorcontrib>Cyganek, K.</creatorcontrib><creatorcontrib>Sztefko, K.</creatorcontrib><creatorcontrib>Seghieri, G.</creatorcontrib><creatorcontrib>Breschi, M. C.</creatorcontrib><creatorcontrib>Waluś-Miarka, M.</creatorcontrib><creatorcontrib>Kawalec, E.</creatorcontrib><creatorcontrib>Seretny, M.</creatorcontrib><creatorcontrib>Sieradzki, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Idzior-Waluś, B.</au><au>Cyganek, K.</au><au>Sztefko, K.</au><au>Seghieri, G.</au><au>Breschi, M. C.</au><au>Waluś-Miarka, M.</au><au>Kawalec, E.</au><au>Seretny, M.</au><au>Sieradzki, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total plasma homocysteine correlates in women with gestational diabetes</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>278</volume><issue>4</issue><spage>309</spage><epage>313</epage><pages>309-313</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract><![CDATA[Aim
We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM).
Methods
We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels were analyzed by ELISA, using Bio-Rad reagents. Serum folates and vitamin B
12
concentrations were determined by chemiluminescent immunoassay, free fatty acids (FFA) and lipids enzymatically.
Results
Serum homocysteine levels were similar in both the GDM and the CG groups (8 ± 2.0 vs 7.4 ± 1.1 μmol/l, respectively). Women with GDM in comparison to CG women were characterized by higher values of homeostasis model of insulin resistance (HOMA-IR) (2.8 ± 1.7 vs 1.6 ± 0.9,
P
< 0.01), serum triglycerides (2.7 ± 0.9 vs 1.9 ± 0.5 mmol/l,
P
< 0.01) and FFA (0.6 ± 0.2 vs 0.46 ± 0.2 mmol/l,
P
< 0.05). In GDM women serum tHcy correlated with vitamin B
12
(
r
= −0.47,
P
< 0.01) and folates (
r
= −0.51,
P
< 0.001); in CG women with HOMA-IR, a marker of insulin resistance (
r
= −0.49,
P
< 0.05). In multiple regression analysis with serum tHcy as a dependent variable, folate and vitamin B
12
entered the analysis in GDM women (beta = −0.42 and −0.34, respectively,
P
< 0.05), whereas in CG cystatin C and HOMA-IR entered the analysis (
P
< 0.05).
Conclusions
In women with GDM, serum homocysteine is significantly associated with vitamin B
12
and folate levels, while in healthy pregnant women with HOMA-IR and with kidney function. The results suggest the importance of the B-group vitamins in regulation of serum tHcy levels in women with insulin resistance/gestational diabetes, what might be relevant in protection against pregnancy complications associated with elevated tHcy in GDM women.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18236055</pmid><doi>10.1007/s00404-008-0571-1</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2008-10, Vol.278 (4), p.309-313 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69448818 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Case-Control Studies Diabetes Diabetes, Gestational - blood Endocrinology Female Folic Acid - blood Gynecology Health risk assessment Homocysteine Homocysteine - blood Human Genetics Humans Insulin Resistance Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Article Pregnancy Vitamin B 12 - blood |
| title | Total plasma homocysteine correlates in women with gestational diabetes |
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