Total plasma homocysteine correlates in women with gestational diabetes

Aim We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM). Methods We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels we...

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Veröffentlicht in:	Archives of gynecology and obstetrics 2008-10, Vol.278 (4), p.309-313
Hauptverfasser:	Idzior-Waluś, B., Cyganek, K., Sztefko, K., Seghieri, G., Breschi, M. C., Waluś-Miarka, M., Kawalec, E., Seretny, M., Sieradzki, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Diabetes Diabetes, Gestational - blood Endocrinology Female Folic Acid - blood Gynecology Health risk assessment Homocysteine Homocysteine - blood Human Genetics Humans Insulin Resistance Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Article Pregnancy Vitamin B 12 - blood
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Zusammenfassung:	Aim We aim to assess serum total homocysteine (tHcy) associations with metabolic syndrome components and B-vitamins in women with gestational diabetes mellitus (GDM). Methods We studied 61 consecutive pregnant women, 44 with GDM and 17 with normal glucose tolerance (CG). Serum homocysteine levels were analyzed by ELISA, using Bio-Rad reagents. Serum folates and vitamin B 12 concentrations were determined by chemiluminescent immunoassay, free fatty acids (FFA) and lipids enzymatically. Results Serum homocysteine levels were similar in both the GDM and the CG groups (8 ± 2.0 vs 7.4 ± 1.1 μmol/l, respectively). Women with GDM in comparison to CG women were characterized by higher values of homeostasis model of insulin resistance (HOMA-IR) (2.8 ± 1.7 vs 1.6 ± 0.9, P
ISSN:	0932-0067 1432-0711
DOI:	10.1007/s00404-008-0571-1