Efficacy and effectiveness of five day treatment of uncomplicated falciparum with artemisinin or artesunate in Vietnam

Efficacy and effectiveness of five day treatment of uncomplicated falciparum with artemisinin or artesunate in Vietnam

A study on efficacy and effectiveness of artemisinin (total dose of 60 mg/kg) and artesunate (total dose of 12 mg/kg over five days) in treatment of uncomplicated malaria was conducted in highly malaria transmitted areas in Vietnam. 126 uncomplicated malaria cases finished 14 day follow-up. 100% cur...

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Veröffentlicht in:Southeast Asian journal of tropical medicine and public health 1999-03, Vol.30 (1), p.3-6
Hauptverfasser: Le, N B, Pham, T Y, Nguyen, B N, Dang, C T, Pham, T L, Le, D C
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - pharmacology
Antimalarials - therapeutic use
Antiparasitic agents
Artemisinins
Biological and medical sciences
Child
Drug Monitoring - methods
Female
Fever - parasitology
Follow-Up Studies
Humans
Lactones - pharmacology
Lactones - therapeutic use
Malaria, Falciparum - blood
Malaria, Falciparum - complications
Malaria, Falciparum - drug therapy
Malaria, Falciparum - parasitology
Male
Medical sciences
Pharmacology. Drug treatments
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Treatment Outcome
Tropical medicine
Vietnam
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Zusammenfassung:A study on efficacy and effectiveness of artemisinin (total dose of 60 mg/kg) and artesunate (total dose of 12 mg/kg over five days) in treatment of uncomplicated malaria was conducted in highly malaria transmitted areas in Vietnam. 126 uncomplicated malaria cases finished 14 day follow-up. 100% cure rate achieved at day 14 in patients of the efficacy groups received either artemisinin or artesunate, while it was 83% and 93% in patients treated respectively with artemisinin and artesunate of the effectiveness groups. Compliance of the treatment regimens was discussed.
ISSN:0125-1562