Quantitation of a novel metalloporphyrin drug in plasma by atomic absorption spectroscopy

A bioanalytical method to quantify cobalt mesoporphyrin (CoMP), a novel therapeutic agent, in plasma has been developed and validated. The approach involves atomic absorption spectroscopy to determine total cobalt in a sample and a back-calculation of the amount of compound present. Endogenous plasm...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1999-03, Vol.19 (3), p.319-326
Hauptverfasser:	Hoffman, Keith L, Feng, M.Rose, Rossi, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Area Under Curve Atomic absorption spectroscopy Biological and medical sciences Carbon Radioisotopes Cobalt - blood Cobalt mesoporphyrin (CoMP) Correlation Evaluation Studies as Topic General pharmacology Linear Models Male Medical sciences Mesoporphyrins - blood Pharmacokinetics Pharmacology. Drug treatments Plasma Radiometry Rats Rats, Wistar Reproducibility of Results Spectrophotometry, Atomic - methods Spectrophotometry, Atomic - standards Xenobiotics
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Beschreibung
Zusammenfassung:	A bioanalytical method to quantify cobalt mesoporphyrin (CoMP), a novel therapeutic agent, in plasma has been developed and validated. The approach involves atomic absorption spectroscopy to determine total cobalt in a sample and a back-calculation of the amount of compound present. Endogenous plasma cobalt concentrations were small (
ISSN:	0731-7085 1873-264X
DOI:	10.1016/S0731-7085(98)00124-1