Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes
We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the C-MYC was amplified. Further analysis with probes located both 3 ′ and 5 ′ of MYC indicated that the amplicon was at least 700 kb in size, extending from the papillom...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1999-07, Vol.112 (2), p.144-148 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Crossen, Peter E Savage, Lynette M Heaton, David C Morrison, Mary J |
| description | We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the
C-MYC was amplified. Further analysis with probes located both 3
′ and 5
′ of
MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5
′ of
MYC to the
PVT gene located 280 kb 3
′ of
MYC. This appears to be the largest
MYC-containing amplicon in human leukemia. |
| doi_str_mv | 10.1016/S0165-4608(98)00260-X |
| format | Article |
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C-MYC was amplified. Further analysis with probes located both 3
′ and 5
′ of
MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5
′ of
MYC to the
PVT gene located 280 kb 3
′ of
MYC. This appears to be the largest
MYC-containing amplicon in human leukemia.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(98)00260-X</identifier><identifier>PMID: 10686942</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Biological and medical sciences ; Chromosome Aberrations ; Genes, myc ; Hematologic and hematopoietic diseases ; Humans ; Karyotyping ; Leukemia, Myeloid - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Cancer genetics and cytogenetics, 1999-07, Vol.112 (2), p.144-148</ispartof><rights>1999 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-daf027f556fa4eb586c3d16f92496f374dac8c87587c95f860088ab1a68a3c173</citedby><cites>FETCH-LOGICAL-c390t-daf027f556fa4eb586c3d16f92496f374dac8c87587c95f860088ab1a68a3c173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-4608(98)00260-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1890346$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10686942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crossen, Peter E</creatorcontrib><creatorcontrib>Savage, Lynette M</creatorcontrib><creatorcontrib>Heaton, David C</creatorcontrib><creatorcontrib>Morrison, Mary J</creatorcontrib><title>Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the
C-MYC was amplified. Further analysis with probes located both 3
′ and 5
′ of
MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5
′ of
MYC to the
PVT gene located 280 kb 3
′ of
MYC. This appears to be the largest
MYC-containing amplicon in human leukemia.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations</subject><subject>Genes, myc</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQQC0EokvpJ4B8QAgOKXacOPYJrUILSFv1AJXKyZp1xlrTJF7sBNR-fb3dFfTGZSzNvPHMPEJecXbKGZcfvuVQF5Vk6p1W7xkrJSuun5AFV40oqqqWT8niL3JEXqT0kzHWlFo-J0ecSSV1VS6IbzcQwU4Y_R1MPow0ODptkLbFxY-WLodt723O-pECbSHhrr6084T04hb74Du6wvkGBw_0j5829FOY130u-nHHtJsYhpDCgOkleeagT3hyeI_J1fnZ9_ZLsbr8_LVdrgorNJuKDhwrG1fX0kGF61pJKzounS4rLZ1oqg6ssqqpVWN17ZRkTClYc5AKhOWNOCZv9_9uY_g1Y5rM4JPFvocRw5xMvls0SogM1nvQxpBSRGe20Q8Qbw1nZufYPDg2O4FGK_Pg2FznvteHAfN6wO5R115qBt4cAEgWehdhtD7945RmopIZ-7jHMNv47TGaZD2OFjsf0U6mC_4_m9wD0i2YGQ</recordid><startdate>19990715</startdate><enddate>19990715</enddate><creator>Crossen, Peter E</creator><creator>Savage, Lynette M</creator><creator>Heaton, David C</creator><creator>Morrison, Mary J</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990715</creationdate><title>Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes</title><author>Crossen, Peter E ; Savage, Lynette M ; Heaton, David C ; Morrison, Mary J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-daf027f556fa4eb586c3d16f92496f374dac8c87587c95f860088ab1a68a3c173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations</topic><topic>Genes, myc</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>online_resources</toplevel><creatorcontrib>Crossen, Peter E</creatorcontrib><creatorcontrib>Savage, Lynette M</creatorcontrib><creatorcontrib>Heaton, David C</creatorcontrib><creatorcontrib>Morrison, Mary J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crossen, Peter E</au><au>Savage, Lynette M</au><au>Heaton, David C</au><au>Morrison, Mary J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1999-07-15</date><risdate>1999</risdate><volume>112</volume><issue>2</issue><spage>144</spage><epage>148</epage><pages>144-148</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the
C-MYC was amplified. Further analysis with probes located both 3
′ and 5
′ of
MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5
′ of
MYC to the
PVT gene located 280 kb 3
′ of
MYC. This appears to be the largest
MYC-containing amplicon in human leukemia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10686942</pmid><doi>10.1016/S0165-4608(98)00260-X</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-4608 |
| ispartof | Cancer genetics and cytogenetics, 1999-07, Vol.112 (2), p.144-148 |
| issn | 0165-4608 1873-4456 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69437833 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Disease Biological and medical sciences Chromosome Aberrations Genes, myc Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged |
| title | Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes |
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