Characterization of the C-MYC Amplicon in a Case of Acute Myeloid Leukemia with Double Minute Chromosomes

We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the C-MYC was amplified. Further analysis with probes located both 3 ′ and 5 ′ of MYC indicated that the amplicon was at least 700 kb in size, extending from the papillom...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1999-07, Vol.112 (2), p.144-148
Hauptverfasser:	Crossen, Peter E, Savage, Lynette M, Heaton, David C, Morrison, Mary J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Biological and medical sciences Chromosome Aberrations Genes, myc Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged
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Zusammenfassung:	We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the C-MYC was amplified. Further analysis with probes located both 3 ′ and 5 ′ of MYC indicated that the amplicon was at least 700 kb in size, extending from the papilloma virus integration site situated 500 kb 5 ′ of MYC to the PVT gene located 280 kb 3 ′ of MYC. This appears to be the largest MYC-containing amplicon in human leukemia.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/S0165-4608(98)00260-X